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391048

Hesperidin mitigates Doxorubicin-induced hepatic toxicity in rats, targeting JAK-STAT signaling pathway

Article

Last updated: 24 Dec 2024

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-

Tags

Experimental Toxicology

Abstract

Even though doxorubicin (DOX) is an excellent cancer chemotherapy, its adverse impacts, including hepatotoxicity, restrict its clinical usefulness. The study's goal was to assess hesperidin's (HSP) hepatoprotective impact in rats exposed to DOX as well as any potential underlying mechanisms. Thirty male albino rats were split into three: DOX, DOX+HSP, and control (10/group). Serum liver enzymes, triglycerides (TG) and cholesterol, hepatic MDA, superoxide dismutase (SOD), serum TNF-α, IL-6, IL-10, liver-expressed JAK2, STAT3 genes, and organ index were assessed. There were additional evaluations of NF-kB and caspase-3 immunoreactions in the liver. The results revealed that hepatic SOD, IL-10, and liver index values all substantially declined in response to DOX-induced damage. But compared to the control group, there was a dramatic rise in the JAK2 and STAT3 genes, as well as hepatic MDA, TNF-α, and IL-6. There was also an increase in blood liver enzymes, serum cholesterol, and TG. In the liver, caspase-3 and NF-kB immunoreactions were also up-regulated. HSP dramatically improved DOX-induced changes in the liver. It can be concluded that, in addition to down-regulating the JAK2/STAT3 signaling cascade, HSP also employed antioxidant, anti-inflammatory, and anti-apoptotic mechanisms to mitigate the hepatotoxicity induced by DOX.

DOI

10.21608/mjfmct.2024.330487.1086

Keywords

caspase3, DOX, Jak2, NF-kB, STAT3

Authors

First Name

Suzan

Last Name

Khodir

MiddleName

A

Affiliation

physiology department, faculty of medicine, menoufia university

Email

suzan.abdalhameed.12@med.menofia.edu.eg

City

menoufia

Orcid

0000-0002-2535-9445

First Name

Alaa

Last Name

Nagy

MiddleName

-

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of medicine, Menoufia University

Email

suzy25186@yahoo.com

City

-

Orcid

-

First Name

Noha

Last Name

Abd El-aziz

MiddleName

-

Affiliation

Anatomy and Embryology Department, Faculty of Medicine, Menoufia University

Email

noha.mohammed935@med.menofia.edu.eg

City

-

Orcid

-

First Name

Amira

Last Name

Mohamed

MiddleName

-

Affiliation

Pharmacology Department, Faculty of medicine, Suez Canal University

Email

hashema877@yahoo.com

City

-

Orcid

-

First Name

samar

Last Name

hussein

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Suez Canal University

Email

samarhussein@yahoo.com

City

-

Orcid

-

First Name

walaa

Last Name

Elgheriany

MiddleName

-

Affiliation

Internal Medicine department Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.

Email

suzy25186@gmail.com

City

-

Orcid

-

First Name

tarek

Last Name

Abd-Elhamid

MiddleName

-

Affiliation

Histology and Cell Biology, Faculty of Medicine, Assiut University Histology, Faculty of Medicine, Aqaba Medical Sciences University

Email

soso_egy89@yahoo.com

City

-

Orcid

-

First Name

Maha

Last Name

Elnady

MiddleName

-

Affiliation

Forensic Medicine and Clinical Toxicology department, Faculty of Medicine, Menoufia University

Email

maha_salah87@yahoo.com

City

-

Orcid

-

First Name

mohamed

Last Name

zayed

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Menoufia University Medical physiology department, Faculty of medicine, king Abdulaziz University

Email

suzy_egy89@gmail.com

City

-

Orcid

-

Related Issue

-2

Receive Date

2024-10-24

Publish Date

2024-11-09

Print ISSN

1110-5437

Online ISSN

2682-3217

Link

https://mjfmct.journals.ekb.eg/article_391048.html

Detail API

https://mjfmct.journals.ekb.eg/service?article_code=391048

Order

391,048

Type

Original Article

Type Code

966

Publication Type

Journal

Publication Title

Mansoura Journal of Forensic Medicine and Clinical Toxicology

Publication Link

https://mjfmct.journals.ekb.eg/

MainTitle

Hesperidin mitigates Doxorubicin-induced hepatic toxicity in rats, targeting JAK-STAT signaling pathway

Details

Type

Article

Created At

24 Dec 2024