Recently, abusers have begun using ketamine for recreation and dissociation, which known in between them by other famous street names such as, Kit-Kat, Special K, K hole, Super K, Cat Valium and special K lub when combined with ethanol. Aim of this study is to evaluate toxicological effect of ketamine and ethanol administration on the kidney of albino rats (biochemical and histopathological study). The total study period was 4 weeks. Thirty two adult albino rats were divided in to four groups as follows; control Group (Group I): (eight rats received intraperitoneal (IP) 1.0 ml of 0.9% saline solution and by gavage 1.0 ml of distilled water), Group II: eight rats received (IP) ketamine (25 mg/kg/d) diluted in 0.9% saline solution and by gavage 1.0 ml of distilled water, Group III :eight rats received (IP) 1.0 ml of 0.9% saline solution and by gavage (5g ethanol /kg body weight/24h) and Group IV :eight rats received(IP) ketamine (25 mg/kg/d) diluted in 0.9% saline solution and by gavage (5g ethanol /kg body weight/24h). This study assessed blood urea and creatinine levels, Oxidative stress indices: determination of the level of malondialdehyde (MDA) in renal tissue and Histopathological examination of kidney tissue was done by light microscope and transmission electron microscope (T.E.M). Results showed increase in blood urea and serum creatinine levels with degenerative changes in kidney.