Background: Keloid and hypertrophic (HTS) scar are frequent complaints in dermatological practice. Patients and doctors may experience severe distress due to these lesions, which sometimes are difficult to cure clinically.
Aim of the work: our study was aiming for comparing the efficacy and safety of Botulinum toxin type A and 5-fluorouracil in management of keloids and HTS.
Patient and method: The study was carried out on 20 cases with keloid and hypertrophic scar; they were allocated into two groups: 1st group was given intra- lesional botulinum toxin type A every one month, while the 2nd group was received weekly intra-lesional 5- Fluorouracil.
Results: Both IL botulinum toxin type A and 5- Fluorouracil (5-FU) were found to be effective and safe in management of keloids and hypertrophic scars. Patients who were treated with Botulinum toxin type A , experienced less complication in comparison to patients who received 5-fluorouracil: less pain, no hyperpigmentation, less ulceration.
Conclusion: Our study found that the use of IL BXT-A and IL 5-FU therapeutic modalities on the management of keloids and hypertrophic scars effective and have tolerable adverse effects.