Background: Pancreaticojejunostomy and pancreaticogastrostomy are the two techniques for pancreatic anastomosis that are widely established for the reconstruction after pancreaticoduodenectomy. Aim: To study the effect of the type of pancreaticoenteric reconstruction pancreaticojejunostomy versus pancreaticogastrostomy (PJ versus PG) after pancreaticoduodenectomy regarding the post-operative mortality and morbidity particularly pancreatic fistula (PF). Patients and Methods: A prospective cohort study included 40 patients with pancreatic or periampullary cancer who undergone pancreaticoduodenectomy. The patients divided randomizly into two groups; Group (A)included 20 patients who had undergone pancreaticojejunostomy reconstruction while group (B) included 20 patients who had undergone pancreaticogastrostomy reconstruction. Results: Mean operative time in group A and B was 7.6 ± 2.2 and 7.2 ± 2.7, mean blood loss 984.7 ± 253.2 and 852.5 ± 152.6, in most of the cases there was a Drains in contact with anastomosis was 85% and 70%, respectively. Also, there is no significant difference between both groups regarding intraoperative data. Considering postoperative complications, there was significant difference between both groups regarding pancreatic fistula, bile leak, postoperative pancreatitis andpeptic ulcer. Conclusion: This study observed that PG is associated with a lower risk for PF compared with PJ.