Background: In young and middle-aged individuals, lumbar disc herniation is a prevalent disease that affects the spine. Objective: To evaluate the efficacy of pulsed radio frequency and transforaminal steroid injection versus SpineMed system in the treatment of radicular pain caused by a herniated lumber disc at levels L4-5 and L5-S1. Patients and Methods: This was a prospective randomized clinical trial carried out on 60 patients aged from 20 to 50 years with lumbar disc herniation at levels L4-5 and L5-S1. At AL-Agouza Rheumatology and rehabilitation center from November 2019 to January 2020. Patients were classified into two equal groups: Group 1 was treated by pulsed radio frequency and transforaminal epidural steroid injection (TFESI) (2ml triamcinolone and 2ml ropivacaine), and Group 2 underwent the SpineMed system program, which comprised of 20 to 25 sessions, each of 30-minutes over a 5-week period. Results: According to the Oswestry disability index, there was a substantial reduction in mean in group I comparing to group II before injection, and after 2 weeks, and after 3 months. According to their complications, we discovered no statistically significant variation among groups. Conclusions: PRF stimulation at DRG with TFESI was superior to SpineMed system in the treatment of refractory radicular pain.