Background: Polycystic ovary syndrome (PCOS) is a metabolic syndrome, characterized by anovulation, hyperandrogenism and polycystic ovary. PCOS exists commonly among women at reproductive age with an incidence rate of 6-10%.
Objective: To study thyroiditis as a risk factor in Polycystic Syndrome Patients.
Patients and Methods: This study was a cross sectional, observation study, this study included all consecutive PCOS patients with thyroiditis visiting the outpatient clinics of the Departments of Obstetrics and Gynecology Dar El-Shefa Damnhour Hospital, carried out on 60 patients divided into two groups: Group (A): 30 PCOS patients (Case group) and Group (B): (30) Non-PCOS patients (Control group). Between December 2019 to December 2020.
Results: Thyroid hormone in PCO group was significantly higher than non PCO group, also the Thyroglobulin antibody and Anti- thyroid peroxidase was significantly higher in PCO group more than non PCO. The Luteinizing hormone, Follicle stimulating hormone and Luteinizing hormone/ Follicle stimulating hormone ratio show insignificant difference between the two studied groups. The hormonal assay including estradiol, progesterone and free testosterone showed a significant increase in PCO patients more than non PCO group. The fasting blood sugar, HOMA Insulin resistance, lipid profile showed a significant increase in PCO group more than non PCO group. Regarding thyroid abnormalities, it was found that there was an increasing in goiter, overt hypothyroid, autoimmune thyroiditis and Graves disease in PCO group more than non PCO.
Conclusion: Thyroiditis considered a risk factor in polycystic syndrome patients and increase the symptoms of PCOs. Patients with thyroid peroxidase and thyroglobulin autoantibodies are likely to develop thyroid dysfunction later in life.