Background: Polycystic ovary syndrome (PCOS) is a common and perplexing endocrine disorder of women in their reproductive years, with a prevalence of up to 10%. Clinical expression of the syndrome varies but commonly includes menstrual cycle disturbance, hyperandrogenism, insulin resistance and obesity. PCOS is not only the most common endocrine disorder in reproductive age women, but also a predominant cause of anovulatory infertility.
Objective: To determine the laparoscopic electrocauterization in patients with PCOS on development of a humoral immunity and production of antiovarian antibodies (AOAs).
Patients and Methods: This prospective cross-sectional study was conducted on 54 reproductive age women (18-35 y of age) with clomiphene citrate–resistant (≥150 mg/d). PCOS were enrolled in as study group, and 26 healthy women of reproductive age (<35 years) had no evidence of autoimmune disease or fertility problems, as a control group. During period from 2017 to 2020 at Al-HusseinUniversityHospital, Al-AzharUniversity. Blood samples were taken before and about 30-40 days after laparoscopic ovarian electrocauterization.
Results: There were 61.1% (33 women out of 54) women ovulated after laparoscopic ovarian drilling (LOD). Before LOD, there were 20.4% (11 women out of 54) women showed regular menstrual pattern and 79.6% (43 out of 54) women complained of irregular menstrual pattern. After LOD, there were 45(83.3%) women restore regular cycles, and 9 (16.7%) still complaining of irregular cycle. This difference was found to be statistically significance difference between before and after LOD (p=0.001) in regularity of the cycles. Antiovarian antibodies assessment of the studied group showed difference before and after LOD and this difference was found to be statistically significant. There was significant relationship between cycle regularity and LH value before and after LOD, and there was significant difference between LH: FSH ratio before and after LOD. The compression between antiovarian antibodies (AOAs) before LOD in study group according luteinising hormone (LH): follicle stimulating hormone (FSH) ratio. There was no significant difference between AOA before LOD in study group according to LH:FSH ratio.
Conclusion: Antiovarian antibodies assessment of the studied group (patients with clomiphene citrate–resistant (≥150 mg/d) PCOS) showed difference before and after LOD, and this difference was found to be statistically significant.