Background: Peptic ulcer is an acid-induced lesion of the digestive tract that is usually located in the stomach or proximal duodenum, and is characterized by denuded mucosa with the defect extending into the submucosa or muscularis propria. Pangastritis commonly seen in upper gastrointestinal (UGI) and we need to take biopsies for histopathology to confirm gastritis histological. Objective: This study aims to analyze the correlation between the endoscopic findings and the histological diagnosis of pan-gastritis in newly diagnosed ulcer dyspeptic patients. Patients and methods: A hospital-based cross-sectional study conducted on 180 patients at Al-Hussien University Hospitals to assess the endoscopic and histopathologic pattern of pan-gastritis among patients presented by newly diagnosed peptic ulcer dyspepsia not more than 4 weeks attending the Hepato-gastroenterology and Infectious diseases Department outpatient clinic and endoscopy unit during, the period from February to August 2019. Results: Results of histopathology compared to endoscopic result in diagnosis of ulcer dyspepsia, we found that 120 patients (66.7%) true positive, 14 patients (7.8%) true negative, 18 patient (10%) false positive and 28 patients (15.6%) false negative. Thus endoscope had the sensitivity of 81.8%, specificity of 43.8%, PPV of 86.9%, NPV of 33.3% and accuracy of 74.4% in diagnosis of pangastritis. Also H.pylori was examined by giemsa stain and found that H.pylori positive in 71.1% of cases which mean significant association between ulcer dyspepsia and H. pylori, mostly was in the antrum was positive in 128 patients (71.1%), H. pylori Body was positive in 88 Patients (48.9%) while H. pylori fundus was positive in 75 patients (41.7% According to symptoms of the patients we find that 41.1 % (74) from ulcer dyspeptic patient cases complaining from epigastric pain then early satiation was positive 70 patients (38.9%), Post prandial fullness was positive 64 patients (35.6%) followed by Epigastric burning was positive in 59 patients (32.8%) of all studied patients. Conclusion: Pan-gastritis is a common finding in ulcer dyspeptic patients and endoscopy has high sensitivity in diagnosis of pangastritis and normal endoscopic appearance does not rule it out and the histopathology is still the gold standard method.