Background: Osteomyelitis is a major problem in orthopedic surgery and is usually associated with open fracture surgery, bone reconstruction surgery, or orthopedic implants. Antibiotics alone cannot eradicate chronic osteomyelitis, surgical debridement and sequestrectomy is required to debride all necrotic and infected bone, soft tissue and sinuses. The treatment of broad bone gaps is still a surgical challenge, and there is no consensus about the best reconstruction methods. Objective: To evaluate the results of Masqulete technique in treatment of chronic osteomyelitis. Patients and Methods: This was a prospective study that was conducted on 10 patients with chronic osteomyelitis done at Al-AzharUniversity and El Minia Health Insurance Hospitals during the period between May 2019 and May 2020. All patients were subjected to Masquelet Procedure, bone ends were debride until bleeding. The bone temporarily stabilized by external fixator, plate or intramedullary nail. The cement spacer was implanted with an overlap to the bone ends to provide a more extensive introduction of the membrane. After several weeks, the resultant then fibrous membrane was incised and the cement spacer removed. The contained void was filled with cancellous autograft. Autograft was obtained from iliac crest.      In the Masquelet Procedure, bone ends were debride until bleeding. The bone temporarily stabilized by external fixator, plate or intramedullary nail. The cement spacer was implanted with an overlap to the bone ends to provide a more extensive introduction of the membrane. After several weeks,the resultant then fibrous membrane was incised and the cement spacer removed. The contained void was filled with cancellous autograft. Autograft was obtained from iliac crest. Results: This study comprised 6 men and 4 women. The average age of the included patients was 44.00 ± 2.62, and the average BMI was 25.20 ± 2.70. Among them 4 (40 %) patients did exercise, 3 (30 %) patients had smoking history, and 3 (30 %) patients had hypertension history. The study showed that post Masque let Technique complications are: 60% of patients had no complications, 20% had partial necrosis at edge of the flap, and 20% had superficial infection around the incision. Conclusion: Masquelet technique was a good new challenge in reconstruction treatment of chronic osteomyelitis with simple surgical procedure and low incidence of postoperative complications.