Background: Surgical site infections (SSIs) are one of the most frequent complications in abdominal surgery. It is associated with prolonged hospital stay, a compromised quality of life and an increase in mortality and in costs. Objective: To assess the prevalence, risk factors and causative organism of surgical sites infection after abdominal surgeries. Patients and methods: Five hundred patients who underwent an abdominal surgery were included in this prospective observational comparative study. The study population was divided into two equal groups: Group (A): Non- comorbidities group and Group (B): Comorbidities group. Patients underwent abdominal surgeries in Ismailia general Hospital and Al-Zahra'a University Hospital. The study was conducted at Ismailia GeneralHospital from November 2020 to June 2021. All patients who were subjected to full medical history, general and systemic examination and laboratory investigation Results: There was an insignificant difference between the groups according to the demographic data. The results showed significant difference between the groups according to the frequency of surgical wound classification, and according to total leukocitic count, C. reactive protein and the fasting blood sugar results (P value >0.001) after the surgery. The result of the treatment followed with the infected site among the study groups after the abdominal procedure showed significant difference between the groups according to the treatment (P value = 0.001). Conclusion: Although surgical site infections cannot be completely eliminated, a reduction in the infection rate to a minimal level could have significant benefits, by reducing postoperative morbidity and mortality, and wastage of health care resources. A pre-existing medical illness, the wound class, and wound contamination strongly predisposed to wound infection.