ManageChatDiscover
399067

Serum Level of P19 Subunit of Human Interleukin 23 in Psoriatic Patients Before & After Phototherapy of Ultra-Violet B (UVB) in Dermatology Outpatient Clinic Suez Canal University

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical Research (Medical)

Abstract

Background:Psoriasis is a skin condition distinguished by inflammation, hyperproliferation of epidermal cells, & a noticeable influx of macrophages, neutrophils, & T lymphocytes. T-helper 1 (Th1) cells were once thought to be the mediating factor in psoriatic inflammation; however, more & more recent research suggests that immunological responses by recently identified Th17 cells have a role in the pathophysiology of psoriasis. Objective: To study the influence of UVB on the serum level of P19 subunit of IL-23 in patients with psoriasis. Patients and Methods: Every patient was chosen at random from the Suez Canal University Hospital's dermatology outpatient clinics. Before their involvement in this study, all patients provided their informed permission. The Suez Canal University Hospital's College of Medicine's Ethical Committee gave the study its approval. A thorough history taking & a general & dermatological clinical examination were performed on each patient. Blood samples were obtained at baseline & one-week post-treatment (week 12) to test P19 subunit of IL-23 level & perform a blind clinical assessment using PASI score calculation. Three factors are used to assess the severity of psoriasis: E stands for erythema; I for infiltration; & D for desquamation.Results:  In our study, 24(80%) of patients were male & 6(20%) patients were female. The mean ± SD of the age of patients is 33.27 ± 10.27 years (range 19-45). Most of the patients 21(70%) were smokers with BMI of (24.18 ± 3.08) ranging from 21 to 33 kg/m2. Regarding psoriasis area & severity, the PASI score was 14.33±4.24 ranging from 10 to 16. Also, 8(26.7%) of cases had positive family history & 15(50%) of patients had stationary courses, 3 (10%) had regressive courses & 12(40%) had progressive course. Half of patients 15(50%) had psoriasis at the head & upper limb, while 18(60%) had disease at trunk & 21(70%) had the disease at the lower limb. Patients had a mean duration of disease of 7.16 ± 2.34 years ranging from 2 to 20 years & mean age of disease onset of 34.74 ± 11.07 ranged from 19 to 45 years old. Conclusion: we found that, UVB treatment resulted in a reduction in P19 subunit of IL23 & also PASI score. Also, there were significant correlations between P19 subunit of IL23, the duration of the disease & PASI score.

DOI

10.21608/scumj.2024.399067

Keywords

Ultra-Violet B, Dendritic cells

Authors

First Name

Moustafa MK.

Last Name

Eiada

MiddleName

-

Affiliation

Department of Dermatology, Venereology & Andrology, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Fadia M.

Last Name

Attia

MiddleName

-

Affiliation

2Department of Clinical Pathology, Faculty of Medicine, Suez Canal University.

Email

-

City

-

Orcid

-

First Name

Nader A.

Last Name

Ismail

MiddleName

-

Affiliation

Department of Dermatology, Venereology & Andrology, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Diana F.

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Dermatology, Venereology & Andrology, Faculty of Medicine, Suez Canal University.

Email

-

City

-

Orcid

-

Volume

27

Article Issue

5

Related Issue

50927

Issue Date

2024-05-01

Receive Date

2024-12-22

Publish Date

2024-05-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_399067.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=399067

Order

7

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Serum Level of P19 Subunit of Human Interleukin 23 in Psoriatic Patients Before & After Phototherapy of Ultra-Violet B (UVB) in Dermatology Outpatient Clinic Suez Canal University

Details

Type

Article

Created At

24 Dec 2024