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385505

Clinical Trial to Assess Efficacy of Fluticasone Nasal Spray and Smell Retraining Therapy on Post COVID-19 Anosmia in Suez Canal University Hospital

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical Research (Medical)

Abstract

Background: Most COVID-19 patients experience loss of smell, a symptom considered a hallmark of the disease. Olfactory training improves olfactory function through frequent sniffing of strong odors. Although oral corticosteroids can sometimes enhance olfactory function, their effects are frequently transient and dissipate when the medication is stopped. Intranasal steroids, however, have been associated with long-term improvement. Aim: To assess the efficacy of Fluticasone nasal spray and smell retraining therapy on post-COVID-19 anosmia. Methods: This is a randomized clinical trial carried out in Suez Canal University Hospital at the ENT department from February 2022 to July 2022. Patients used Fluticasone nasal spray once daily,2 puffs per nostril (200mcg) for 3 months. Smell retraining therapy involved repeat sniffing of a set of odorants (commonly lemon, rose, cloves, and eucalyptus) for 20 seconds each at least twice a day for 3 months. Patients were tested 1 month, 2 months, and 3 months from the start of treatment, and they were offered a yes or no questionnaire if they could identify various smells. History and examination were carried out in person using the questionnaire. Results: There was a statistically significant negative correlation between age and olfactory improvement. There was a statistically significant difference between the presence of chronic disease and olfactory improvement. There was a statistically significant positive correlation between the duration of smell loss and the start of improvement. Conclusion: Olfactory training and fluticasone nasal spray are effective for treating post-COVID-19 anosmia.

DOI

10.21608/scumj.2024.385505

Keywords

anosmia, Olfactory training, steroids, Odorants

Authors

First Name

Samar A.

Last Name

Khedr

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt.

Email

drsamaralikhedr@gmail.com

City

Ismailia

Orcid

-

First Name

Mohammed

Last Name

El-Tabakh

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Mahmoud M.

Last Name

Soliman

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Yehia M.

Last Name

Ashry

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

Volume

27

Article Issue

5

Related Issue

50927

Issue Date

2024-05-01

Receive Date

2024-10-11

Publish Date

2024-05-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_385505.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=385505

Order

4

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Clinical Trial to Assess Efficacy of Fluticasone Nasal Spray and Smell Retraining Therapy on Post COVID-19 Anosmia in Suez Canal University Hospital

Details

Type

Article

Created At

24 Dec 2024