Beta
ManageSearchChatDiscover
386657

Efficacy of Hematological Biomarkers as Prognostic Factors for the Severity and Mortality of COVID-19 Patients at Suez Canal University Hospital

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical Research (Medical)

Abstract

Background: The global healthcare systems have faced considerable challenges due to the coronavirus disease 2019 pandemic. It is essential to comprehend the prognostic factors linked to disease severity and mortality for the effective management and treatment of individuals affected by coronavirus disease 2019.Aim: To assess the effectiveness of the laboratory biomarkers as prognostic factors for the severity and mortality of COVID-19 patients at Suez Canal University Hospital. Subjects and Methods: A retrospective cross-sectional study on COVID-19 patients admitted to Suez Canal University Hospital Isolation Centre was conducted. Data on hematological biomarkers, including complete blood count parameters, inflammatory markers, coagulation profiles, and organ-specific markers, were collected. The patients were classified based on disease severity and mortality outcomes. Statistical analyses were conducted to evaluate the correlation between hematological biomarkers and the outcomes of patients. Results: Throughout our study; It was found that IL-6, D-Dimer, ferritin, and Procalcitonin have the highest area under the curve with the higher sensitivity, specificity, positive and negative likelihood ratio for prediction of mortality among the studied patients, while ferritin, IL-6, D-Dimer and Procalcitonin have the highest area under the curve with the higher sensitivity, specificity, positive and negative likelihood ratio for prediction of ICU admission among the studied patients. Conclusion: IL-6, D-Dimer, ferritin, Procalcitonin, lymphocytes, and NLR on admission are significant predictors of in-hospital mortality. In contrast, ferritin, IL-6, D-Dimer, Procalcitonin, lymphocytes, NLR, and CRP on admission are significant predictors of ICU admission.

DOI

10.21608/scumj.2024.386657

Keywords

COVID-19, Laboratory biomarkers, Prognostic factors, severity, mortality

Authors

First Name

Mahmoud E.

Last Name

Mahmoud

MiddleName

-

Affiliation

Chest Diseases Unit, Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Amr MH.

Last Name

Mohamed

MiddleName

-

Affiliation

Chest Diseases Unit, Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Ayman ME.

Last Name

El Mokadem

MiddleName

-

Affiliation

Chest Diseases Unit, Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Ahmed IM.

Last Name

Hafez

MiddleName

-

Affiliation

Chest Diseases Unit, Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

Volume

27

Article Issue

5

Related Issue

50927

Issue Date

2024-05-01

Receive Date

2024-10-16

Publish Date

2024-05-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_386657.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=386657

Order

3

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Efficacy of Hematological Biomarkers as Prognostic Factors for the Severity and Mortality of COVID-19 Patients at Suez Canal University Hospital

Details

Type

Article

Created At

24 Dec 2024