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386690

Diagnostic Utility of Serum Angiopoietin-2 in Diabetic Nephropathy

Article

Last updated: 24 Dec 2024

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Tags

Clinical Research (Medical)

Abstract

Background: Diabetes mellitus (DM) is a major global cause of death. Diabetic nephropathy (DN) is the main microvascular complication of DM. Angiopoietin-2 (Angpt-2) enhances the progression of T2DM and accelerates vascular complications. Patients and Methods: 84 participants were recruited at Suez Canal University Hospital, Ismailia, Egypt, and divided into three equal groups: group I: patients with T2DM without albuminuria (n = 28), group II: patients with T2DM with albuminuria (n = 28), and group III: healthy volunteers (n = 28). For all participants. Laboratory work included serum creatinine, eGFR, UACR, glycemic markers, a lipid profile, and serum Angpt-2 by an ELISA-based method. Results: There was no statistically significant difference between patients with or without albuminuria regarding BMI, blood pressure, lipid profile, and glycemic control. Angpt-2 was significantly higher in patients with microalbuminuria and macroalbuminuria compared to normoalbuminuric diabetic patients and healthy controls, indeed, serum Angpt-2 progressively increases with the progression of albuminuria and renal impairment, Serum Angpt-2 showed a positive correlation with serum creatinine and a negative correlation with eGFR. Conclusions: Angpt-2 was significantly higher in albuminuric diabetic patients than the healthy controls, and it also progressively increased with the progression of UACR.  the increased level of Angpt-2 may be associated with the development of CKD, and could be used as a diagnostic marker for diabetic nephropathy and its progression
 

DOI

10.21608/scumj.2024.386690

Keywords

Angiopoietin-2, diabetic nephropathy, Egypt

Authors

First Name

Sara FM.

Last Name

Elaraby

MiddleName

-

Affiliation

Department Clinical and Chemical Pathology, Faculty of Medicine, Suez Canal University, Egypt.

Email

fathy_sara11@yahoo.com

City

ismailia

Orcid

-

First Name

Nevene R.

Last Name

Wissa

MiddleName

-

Affiliation

Department Clinical and Chemical Pathology, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohammed M.

Last Name

Keshawy

MiddleName

-

Affiliation

Department of Internal Medicine, Nephrology Division, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Nashwa R.

Last Name

Hassan

MiddleName

-

Affiliation

Department Clinical and Chemical Pathology, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

Volume

27

Article Issue

5

Related Issue

50927

Issue Date

2024-05-01

Receive Date

2024-10-17

Publish Date

2024-05-01

Page Start

9

Page End

19

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 27_Issue 5_Pages 9-19.pdf

PDF . 446.0kB

Link

https://scumj.journals.ekb.eg/article_386690.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=386690

Order

2

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Diagnostic Utility of Serum Angiopoietin-2 in Diabetic Nephropathy

Details

Type

Article

Created At

24 Dec 2024