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382100

Comparison of (Nepafenac 0.1%) versus (Prednisolone Acetate 1%) Ophthalmic Suspensions Regarding the Effect on Ocular Inflammation and Central Macular Thickness After Uneventful

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

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Tags

Clinical Research (Medical)

Abstract

Background: Cataract surgery induces an inflammatory response, which may cause serious adverse events if left untreated. Aim: The study compares nepafenac 0.1% eye drops (ED) versus prednisolone acetate 1% ED regarding the effect on ocular inflammation and central macular thickness (CMT). Subjects and Methods: A randomized clinical trial was conducted on patients who underwent phacoemulsification at Suez Canal University Hospital. Patients were divided into two groups: *Group (A): Used Nepafenac 0.1% *Group (B): Used prednisolone acetate 1%. All patients were scheduled for follow-up on days 1, 4, 7, and 30 after surgery, where visual acuity (VA); Intraocular pressure (IOP), and ocular inflammation were assessed. CMT was evaluated on days 7 and 30. Results: Regarding postoperative VA, IOP, and ocular inflammation no statistically significant difference was found between the two groups. Regarding ocular discomfort photophobia, and central corneal thickness (CCT) a statistically significant difference was found between the two groups at postoperative day 7; where for nepafenac and prednisolone mean ± SD of ocular discomfort was 1.20 ± 0.41 and 1.68 ± 0.75, respectively(P=0.007) and for CCT was 543.40 ± 42.13 and 580.36 ± 52.02, respectively(P=0.008). There was a statistically significant difference between the two groups regarding the change of post-operative CMT from the baseline at postoperative day 30, where the mean was 3.68 ± 33.96 and 26.0 ± 28.14 for nepafenac and prednisolone, respectively (P=0.017). Conclusion: Topical nepafenac can be an excellent alternative to topical steroids after cataract surgery.
 

DOI

10.21608/scumj.2024.382100

Keywords

cataract surgery, Eye inflammation, CMT, Anti-inflammatory eye drops

Authors

First Name

Omnia S.

Last Name

Othman

MiddleName

-

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

omnia.saadeldin@med.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Osama M.

Last Name

EL-Nahrawy

MiddleName

-

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Khaled A.

Last Name

Zaky

MiddleName

-

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Ehab M.

Last Name

Moawad

MiddleName

-

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

Volume

27

Article Issue

4

Related Issue

50398

Issue Date

2024-04-01

Receive Date

2024-09-27

Publish Date

2024-04-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_382100.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=382100

Order

5

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Comparison of (Nepafenac 0.1%) versus (Prednisolone Acetate 1%) Ophthalmic Suspensions Regarding the Effect on Ocular Inflammation and Central Macular Thickness After Uneventful Phacoemulsification

Details

Type

Article

Created At

24 Dec 2024