Beta
ManageSearchChatDiscover
381370

Evaluation of Neuroprotective Role of Coenzyme Q 10 in Attenuating Changes of Hippocampus Induced by Diet Coke Consumption in Adult Male Albino Rats

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Basic Research

Abstract

Background: Diet Coke contains a non-nutritive sweetener; aspartame may lead to memory loss and changes in behavior. Coenzyme Q 10 is a powerful endogenous antioxidant within the inner membrane of mitochondria. It has a neuroprotective effect against lipid peroxidation and impairment of memory in aged animals. Aim: To evaluate Coenzyme Q 10's ameliorative effects on the histopathological changes caused by Diet Coke consumption in adult male albino rats, using histological and immunohistochemical techniques. Subjects and Methods: 40 adult male albino rats were equally randomized into 4 groups and received all treatments for 21 days. Group I, control. Group II, Coenzyme Q 10; a daily oral dose of 200 mg/kg was administered. Group III was given orally twice a day, 2.5 ml of diet Coke. Group IV, Coenzyme Q 10 with Diet Coke was given concomitantly. All animals were sacrificed after 21 days. Sections stained with Hematoxylin and Eosin stain, Mallory's phosphotungestic acid hematoxylin (PTAH), and Cresyl fast violet stains. Glial fibrillary acidic protein (GFAP) and caspase 3 immunostaining were also used. Results: Coenzyme Q 10 reversed almost all the histopathological changes induced by Diet Coke and decreased caspase 3 and GFAP immunoreaction, in the hippocampus CA3 region. Conclusion: Coenzyme Q 10 has an ameliorative role in attenuating histopathological changes in the hippocampus induced by Diet Coke consumption in adult male albino rats.
 

DOI

10.21608/scumj.2024.381370

Keywords

Pyramidal Cells, GFAP, Caspase 3, Aspartame

Authors

First Name

Horeya E.

Last Name

Korayem

MiddleName

-

Affiliation

Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

George N.

Last Name

Refaat

MiddleName

-

Affiliation

Departments of Internal Medicine & Cardiology, Suez Canal Authority, Egypt.

Email

-

City

-

Orcid

-

First Name

Mona

Last Name

Awny

MiddleName

-

Affiliation

Forensic Medicine & Clinical Toxicology Department, Faculty of Medicine, Suez Canal University, Egypt.

Email

mona_gioconda@yahoo.co.uk

City

-

Orcid

0000-0002-1021-4163

First Name

Ereny

Last Name

Fekry

MiddleName

-

Affiliation

Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Egypt.

Email

ereny.fekry.81@hotmail.com

City

-

Orcid

0000-0003-4585-4264

Volume

27

Article Issue

4

Related Issue

50398

Issue Date

2024-04-01

Receive Date

2024-09-24

Publish Date

2024-04-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_381370.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=381370

Order

3

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Evaluation of Neuroprotective Role of Coenzyme Q 10 in Attenuating Changes of Hippocampus Induced by Diet Coke Consumption in Adult Male Albino Rats

Details

Type

Article

Created At

24 Dec 2024