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380310

Detection of Subclinical Right Ventricular Dysfunction in Patients with Hepatitis C Virus Infection by Speckle Tracking Echocardiographic Assessment

Article

Last updated: 24 Dec 2024

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Clinical Research (Medical)

Abstract

Background: Hepatitis C virus (HCV) infection is associated with cardiac dysfunction, affecting patients' morbidity and mortality. This study aimed at assessing whether myocardial deformation indices by two- (2D) and three-dimensional (3D) speckle tracking echocardiography can be used as an early imaging biomarker of right ventricular (RV) function affection in HCV patients even in early stages without significant hepatic cirrhosis. Subjects and Methods: 54 HCV patients were recently diagnosed by PCR and classified as Child Paugh A without previous cardiovascular events, and 54 matched healthy controls were enrolled. RV function was assessed using the transthoracic echocardiography conventional and advanced deformation assessment by speckle tracking including global longitudinal and segmental strain. Results: All conventional parameters resulted in the normal range without significant differences between HCV and controlsincluding RIMP, TAPSE, FAC, and S' velocity (P value: 0.41, 0.11, 0.74, and 0.11, respectively). Only the apical RV free wall segment longitudinal strain by speckle tracking was more impaired than controls (-19.19 ± -7.23 vs. -21.64 ± -2.07, P value: <0.001). At the same time, the Global longitudinal strain (-24.2 ± -4.91% vs. -24.98 ± -2.61%, p = 0.171) was similar in both groups. Conclusion: Speckle tracking can detect subclinical RV dysfunction in HCV patients even with normal baseline conventional parameters.
 

DOI

10.21608/scumj.2024.380310

Keywords

Hepatitis C virus, Right ventricular dysfunction, RV Speckle tracking

Authors

First Name

Islam Z.

Last Name

Mahmoud

MiddleName

-

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

islam.z.mahmoud@med.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Ahmed H.

Last Name

Abdel-Moneim

MiddleName

-

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

First Name

Hesham H.

Last Name

Ali

MiddleName

-

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

First Name

Enas A.

Last Name

Ismail

MiddleName

-

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

Volume

27

Article Issue

4

Related Issue

50398

Issue Date

2024-04-01

Receive Date

2024-09-17

Publish Date

2024-04-01

Page Start

1

Page End

8

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 27_Issue 4_Pages 1-8.pdf

PDF . 314.4kB

Link

https://scumj.journals.ekb.eg/article_380310.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=380310

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Detection of Subclinical Right Ventricular Dysfunction in Patients with Hepatitis C Virus Infection by Speckle Tracking Echocardiographic Assessment

Details

Type

Article

Created At

24 Dec 2024