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377581

Assessment of Serum and Urinary Adiponectin as Biomarkers in Type 2 Diabetic Patients with Diabetic Nephropathy

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Last updated: 04 Jan 2025

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Abstract

Background: Worldwide, there are many complications of Type 2 diabetes mellitus (T2DM) and the most common one is diabetic nephropathy (DN). Long-standing diabetic patients had a high risk of developing renal failure due to diabetic nephropathy. Adiponectin may be regarded as a marker of kidney damage and a risk factor for developing the disease. Aim: to determine the association between changes in serum and urinary adiponectin, and diabetic nephropathy in T2DM patients compared to healthy controls. Subjects and Methods: This study involved 80 participants: 40 type 2 diabetic patients and 40 healthy controls. All were subjected to glycemic markers, serum creatinine, urea, and urinary albumin/creatinine ratio using a fully automated auto-analyzer Cobas 6000. Fasting insulin, serum, and urine adiponectin levels using immunosorbent assay method (Enzyme-linked). HOMA-IR and eGFR were calculated. Results:Both serum & urinary adiponectin levels are statistically lower among diabetic patients than healthy controls.The patient groups were subdivided according to the presence of albuminuria into three subgroups: normal albuminuria, microalbuminuria, and macroalbuminuria. No significant difference between the three DM subgroups regarding serum or urine adiponectin. The levels of urine and serum adiponectin significantly correlated positively. Conclusion: Adiponectin levels (serum and urine) were generally low in T2DM patients. Serum adiponectin level decreased more in T2DM patients with microalbuminuria (DN) than increased in T2DM patients with macroalbuminuria. This study suggested that serum and urine adiponectin may not be used to predict diabetic nephropathy among patients with type 2 diabetes.
 

DOI

10.21608/scumj.2024.377581

Keywords

T2DM, DN, serum adiponectin, urine adiponectin

Authors

First Name

Aya A

Last Name

Amer

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

ayaamersemidr@gmail.com

City

-

Orcid

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First Name

Shaymaa A.

Last Name

Abd El-Hady

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed M.

Last Name

Mossad

MiddleName

-

Affiliation

Department of Internal Medicine and Endocrinology, Faculty of Medicine, Suez Canal University.

Email

-

City

-

Orcid

-

First Name

Essam M.

Last Name

Abdalla

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

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-

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-

Orcid

-

Volume

27

Article Issue

3

Related Issue

46644

Issue Date

2024-03-01

Receive Date

2024-09-01

Publish Date

2024-03-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_377581.html

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https://scumj.journals.ekb.eg/service?article_code=377581

Order

4

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Assessment of Serum and Urinary Adiponectin as Biomarkers in Type 2 Diabetic Patients with Diabetic Nephropathy

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Article

Created At

24 Dec 2024