Beta
ManageSearchChatDiscover
345888

Immunohistochemical Expression of Mortalin in Vitiligo Patients

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical Research (Medical)

Abstract

Background: Vitiligo is the most common skin disease, that leads to progressive loss of skin resident melanocytes. The cause of vitiligo has not been universally agreed upon yet. Mortalin (Hsp70 family member) is an anti-apoptotic protein, having different functions such as protein folding, oxidative stress regulation, and intracellular transport, in addition to being one of the cellular chaperones. Mortalin is involved in melanogenesis. Aim: This study aimed to assess the immunohistochemical expression of Mortalin in vitiligo patients' skin, and its correlation with disease clinical pattern, activity, and severity. Subjects and Methods: Tissue expression of Mortalin was assessed using immunohistochemical technique in the skin of 40 vitiligo patients (lesional and perilesional skin) and 40 healthy controls and analyzed by image analyzing software. Vitiligo disease activity and severity were assessed by using the Vitiligo disease activity (VIDA) score, and Vitiligo extent score (VES). Results: Mean immunohistochemical tissue expression (percentage of area stained) of mortal in lesional skin biopsies of vitiligo patients were significantly higher than perilesional skin (p1<0.001) and control skin (p < sub>2<0.001) biopsies. It was found that mortalin tissue expression in lesional and perilesional skin biopsies showed no significant relation to clinical patterns. In lesional skin biopsies, tissue expression of mortalin was significantly related and inversely proportional to VIDA (p=0.019), and VES (p=0.026). Conclusions: Results indicate a possible relation between mortalin and melanocyte loss in vitiligo. The results support the possible future use of mortalin as treatment in vitiligo patients, owing to its anti-apoptotic and stress regulatory action, and its role in inducing melanogenesis. It can also be used as a marker of disease activity and progression.
 

DOI

10.21608/scumj.2024.345888

Keywords

Mortalin, non-segmental vitiligo, melanogenesis, Oxidative Stress, Tissue expression

Authors

First Name

Maha G.

Last Name

Tawfik

MiddleName

-

Affiliation

Department of Dermatology, Venereology, and Andrology, Faculty of Medicine Suez Canal University, Egypt.

Email

maha_gamal@med.suez.edu

City

-

Orcid

-

First Name

Moustafa MK.

Last Name

Eyada

MiddleName

-

Affiliation

Department of Dermatology, Venereology, and Andrology, Faculty of Medicine Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Mona A.

Last Name

Atwa

MiddleName

-

Affiliation

Department of Dermatology, Venereology, and Andrology, Faculty of Medicine Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Amal HA.

Last Name

Gomaa

MiddleName

-

Affiliation

Department of Dermatology, Venereology, and Andrology, Faculty of Medicine Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed K.

Last Name

El-kherbetawy

MiddleName

-

Affiliation

Department of Pathology, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

Volume

27

Article Issue

3

Related Issue

46644

Issue Date

2024-03-01

Receive Date

2024-03-15

Publish Date

2024-03-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_345888.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=345888

Order

3

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Immunohistochemical Expression of Mortalin in Vitiligo Patients

Details

Type

Article

Created At

24 Dec 2024