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381128

Association between Vascular Endothelial Growth Factor Gene +405 C/G Polymorphism and Acute Coronary Syndrome

Article

Last updated: 24 Dec 2024

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Tags

Clinical Research (Medical)

Abstract

Background: Acute coronary syndrome (ACS) is an acute condition that results from decreased blood flow to the coronary arteries. According to the WHO 2020 census, 32.40% of total deaths in Egypt are due to coronary heart diseases, ranking Egypt #15 in the world. ACS is a wide spectrum including ST-segment elevation myocardial infarction, non-ST segment elevation myocardial infarction, and unstable angina. Many risk factors contribute to the etiology of ACS including lifestyle, environmental, and genetic factors. Vascular endothelial growth factor gene polymorphism is one of the genetic elements that may share in the progression of ACS. Aims: to identify the association between VEGF gene +405 C/G polymorphism and acute coronary syndrome. Methods: We designed a descriptive, case-control study. Patients were randomly recruited from March 2021 to October 2021. Fifty patients diagnosed with ACS (35 STEMI_ 10 NSTEMI_ 5 unstable angina) by laboratory tests and imaging and 50 healthy individuals, both groups were age and sex-matched. Initially, we isolated the total DNA from peripheral blood, then we investigated single nucleotide polymorphisms of VEGF (rs 2010963) and the genotyping was performed by PCR-RFLP technique. Results: Our results revealed a significant association between the +405 CC genotype (p=0.025) and acute coronary syndrome. Patients with ACS had significantly more history of diabetes mellitus in comparison with the non-ACS group (p=0.037), while regarding smoking and lipid profile, there was no statistically significant difference between the two groups. Conclusion:  This study proves the existence of an association between VEGF gene polymorphisms (rs2010963) and susceptibility to ACS, so SNPs in VEGF need further investigation as prognostic markers and indicators of angiogenic potential stimulating the formation of collaterals.
 

DOI

10.21608/scumj.2024.381128

Keywords

STEMI, NSTEMI, Atherosclerosis, risk factors, RFLP

Authors

First Name

Manar H.

Last Name

Fathy

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

manarhassan817@gmail.com

City

Ismailia

Orcid

-

First Name

Omar M.

Last Name

Saleh

MiddleName

-

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Nahed Y.

Last Name

Abd Elrazek

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed O.

Last Name

Abdalla

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

27

Article Issue

3

Related Issue

46644

Issue Date

2024-03-01

Receive Date

2024-09-23

Publish Date

2024-03-01

Page Start

13

Page End

22

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 27_Issue 3_Pages 13-22.pdf

PDF . 363.8kB

Link

https://scumj.journals.ekb.eg/article_381128.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=381128

Order

2

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Association between Vascular Endothelial Growth Factor Gene +405 C/G Polymorphism and Acute Coronary Syndrome

Details

Type

Article

Created At

24 Dec 2024