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342793

Age-related Neovascularization Response to Intravitreal Anti-vascular Endothelial Growth Factor

Article

Last updated: 24 Dec 2024

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Tags

Clinical Research (Medical)

Abstract

Background: A medical disorder called age-related macular degeneration (AMD) can cause impaired or absent vision in the center of the visual field. Initially, there are frequently no symptoms. A non-invasive imaging method called Spectral Domain Optical Coherence Tomography (SD-OCT) can show structural alterations in the retinal pigment epithelium (RPE) and neurosensory retina. Anti-vascular endothelial growth factor Anti-VEGF is often administered intravitreally to slow or stop the formation of blood vessels by blocking its interaction with receptors on the surface of endothelial cells. Aim: To describe changes in age-related choroidal neovascularization CNV to intravitreal anti-VEGF using OCTA. Methods: We conducted a prospective quasi-experimental study on 30 eyes of patients with neovascular AMD at the Suez Canal University Hospital's Ophthalmic Outpatient Clinic to observe how CNV responded to anti-VEGF for improved visual results and more effective follow-up in this patient group. Results: There was a highly statistically significant difference between different periods regarding both CNV area (p < 0.001), and CNV fine vessel density (p < 0.001). Conclusion: OCT-A is a quick, non-invasive, and repeatable way to examine exudative AMD. It offers precise data on the region of the CNV that responds to anti-VEGF treatment, and it is a promising imaging technique that permits assessment of the CNV fine vascular density response to anti-VEGF.
 

DOI

10.21608/scumj.2024.342793

Keywords

macular degeneration, Optical Coherence Tomography

Authors

First Name

Mohamed S.

Last Name

Omar

MiddleName

-

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Egypt

Email

mohamedsalahophtha@gmail.com

City

-

Orcid

-

First Name

Osama M.

Last Name

ELBassiouny

MiddleName

-

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Hussein S.

Last Name

EL-Nahass

MiddleName

-

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Tarak M.

Last Name

Radwan

MiddleName

-

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mervet E.

Last Name

Elgharib

MiddleName

-

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

27

Article Issue

1

Related Issue

45916

Issue Date

2024-01-01

Receive Date

2024-02-23

Publish Date

2024-01-01

Page Start

73

Page End

82

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 27_Issue 1_Pages 73-82.pdf

PDF . 254.6kB

Link

https://scumj.journals.ekb.eg/article_342793.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=342793

Order

8

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Age-related Neovascularization Response to Intravitreal Anti-vascular Endothelial Growth Factor

Details

Type

Article

Created At

24 Dec 2024