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342791

Efficacy and Safety of Dexmedetomidine Combined with Bupivacaine in Infants’ Surgeries: A Randomized Controlled Trial

Article

Last updated: 24 Dec 2024

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Subjects

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Tags

Clinical Research (Surgical)

Abstract

Background: Dexmedetomidine has been identified as a good sedative agent in adult patients. It is usually added to local anesthetic in spinal anesthesia (SA). However, its use as an adjuvant in infant surgeries has not been well studied due to the scarcity of data. Aim: In this study, we aim to investigate the efficacy and safety of dexmedetomidine combined with bupivacaine in SA. Materials and Methods: in this randomized clinical trial, we included 46 infants who underwent infra-umbilical surgeries. We allocated patients into two groups: group 1 received bupivacaine only, and group 2 received 0.3μg/kg dexmedetomidine in addition to bupivacaine 0.5%. We assessed efficacy through evaluation of the onset and duration of sensory and motor block and time to discharge from the post-anesthesia care unit (PACU), while safety was assessed through monitoring of hemodynamics and rate of complications. Results: we found that using 0.3μg/kg dexmedetomidine in addition to bupivacaine 0.5% (group 2) was associated with a significantly prolonged duration of sensory and motor block compared to group 1. Time to discharge from PACU was earlier with group 2, but not significantly different from group 1. Although Group 1 did not witness any complications; group 2 had limited side effects that were managed appropriately. Conclusions: the combination of 0.3μg/kg dexmedetomidine with bupivacaine is safe and efficient in the anesthesia of infants undergoing minor surgeries.
 

DOI

10.21608/scumj.2024.342791

Keywords

Infra umbilical surgeries, Dexmedetomidine, Bupivacaine, infants, Spinal anesthesia

Authors

First Name

Ahmed N.

Last Name

Negm

MiddleName

-

Affiliation

Department of Anesthesia, Faculty of Medicine, Suez Canal University, Egypt

Email

ahmed.nader@med.suez.edu.eg

City

-

Orcid

0009-0006-4808-062X

Volume

27

Article Issue

1

Related Issue

45916

Issue Date

2024-01-01

Receive Date

2024-02-23

Publish Date

2024-01-01

Page Start

41

Page End

52

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 27_Issue 1_Pages 41-52.pdf

PDF . 441.5kB

Link

https://scumj.journals.ekb.eg/article_342791.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=342791

Order

5

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Efficacy and Safety of Dexmedetomidine Combined with Bupivacaine in Infants’ Surgeries: A Randomized Controlled Trial

Details

Type

Article

Created At

24 Dec 2024