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342710

Utility of Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging of the Brain in Patients with Hashimoto’s Thyroiditis with Normal Appearing Conventional Brain MRI

Article

Last updated: 24 Dec 2024

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Clinical Research (Medical)

Abstract

Background: Hashimoto's thyroiditis (HT) is a known autoimmune disease of the thyroid gland and is usually associated with cognitive disorders. Aim: To investigate the utility of brain magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) in the detection of any metabolic or microstructural changes in HT patients who have normal conventional brain MRI, in correlation to thyroid peroxidase antibodies (TPOAb) levels and disease duration. This case-control study involved 40 patients with HT and 20 healthy controls. All the patients were euthyroid at the examination time and underwent hormonal assessment (TSH, T3, T4), TPOAb titer, brain MRS, and DTI. Correlations between MRS ratios, DTI values, TPOAb titer, and disease duration were performed. Results: Lower NAA/Cr and higher mI/Cr ratios in posterior cingulate gyrus (PCG) and parietal white matter (PWM) were observed in patients than in healthy controls (p= 0.001). A lower value of fractional anisotropy (FA), radial diffusivity (RD), and higher mean diffusivity (MD), and axial diffusivity (AD) were observed in patients versus control groups. Moderate positive correlation between disease duration and mI/Cr in PCG and PWM areas, and RD in the corpus callosum (p= 0.021, 0.013, 0.025, respectively), a moderate negative correlation between TPOAB and NAA/Cr in PCG, FA in the posterior limb of the internal capsule (PLIC) (r = − 0.536, p= 0.001, r = –0.436, p= 0.028 respectively). Conclusion: Brain MRS and DTI showed metabolic and microstructural changes in neurocognitive-related regions in patients with HT, which will help in understanding the concomitant neurocognitive deficits and disease management.
 

DOI

10.21608/scumj.2024.342710

Keywords

DTI, Fractional anisotropy, Hashimoto’s Thyroiditis, MRS

Authors

First Name

Heba R.

Last Name

Ibrahim

MiddleName

-

Affiliation

Department of Diagnostic Radiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

h.refaat83@yahoo.com

City

-

Orcid

-

Volume

27

Article Issue

1

Related Issue

45916

Issue Date

2024-01-01

Receive Date

2024-02-23

Publish Date

2024-01-01

Page Start

31

Page End

40

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 27_Issue 1_Pages 31-40.pdf

PDF . 581.2kB

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https://scumj.journals.ekb.eg/article_342710.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=342710

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4

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Utility of Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging of the Brain in Patients with Hashimoto’s Thyroiditis with Normal Appearing Conventional Brain MRI

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Article

Created At

24 Dec 2024