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Evaluation of Effects of Antiepileptic Drugs on Pulmonary Functions in Children with Idiopathic Epilepsy Attending Neurology Outpatient Clinic in the National Institute of Neurom

Article

Last updated: 04 Jan 2025

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Tags

Clinical Research (Medical)

Abstract

Background: Epilepsy is one of the most common neurological diseases affecting human health and requires long-term treatment. Monitoring the side effects of the drugs used in treatment is therefore very important, particularly in pediatric patients. Aim: To detect the effects of some antiepileptic drugs (valproic acid and carbamazepine) on pulmonary functions in children with idiopathic epilepsy aiming to decrease morbidity and mortality.Patients and Methods: A case control study included 63 children including 36 males and 27 females aged between 6:14 years old, 42 epileptic patients, and 21 healthy children as controls. Patients were divided into 21 patients treated with one drug (either valproic acid or carbamazepine) and 21 patients treated with combined therapy of valproic acid and carbamazepine. Pulmonary function test using spirometry was performed on both patients and controls who were age and sex-matched. Results: We found a statistically significant decrease in all pulmonary functions in children receiving antiepileptic drugs compared to normal individuals. Regarding pulmonary functions, (Peak-expiratory flow) PEF% was the most affected function with a mean of 91% in normal children, 80% in the monotherapy group, and 68% in the polytherapy group. Whereas there was no statistically significant difference in PFTs in the monotherapy group compared to polytherapy one. Moreover, we found a statistically significant reduction in pulmonary functions in patients and an increase in the duration of treatment particularly in the CBZ group. Conclusion: Treatment with antiepileptic drugs for a prolonged time can affect pulmonary functions in epileptic children in the form of a restrictive pattern.  

DOI

10.21608/scumj.2023.324267

Keywords

Valproic acid, carbamazepine

Authors

First Name

Samar M.

Last Name

Dawoud

MiddleName

-

Affiliation

Department of Pediatrics, National Institute of Neuromotor System, Egypt.

Email

s.m.dawoud@hotmail.com

City

Cairo

Orcid

-

First Name

Hesham F.

Last Name

Elsayed

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine-Suez Canal University.

Email

-

City

-

Orcid

-

First Name

Mohammed H.

Last Name

Elsabagh

MiddleName

-

Affiliation

Department of Pediatrics, National Institute of Neuromotor System, Egypt.

Email

-

City

-

Orcid

-

First Name

Ahmed E.

Last Name

Ebrahim

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine-Suez Canal University.

Email

-

City

-

Orcid

-

Volume

26

Article Issue

9

Related Issue

44148

Issue Date

2023-09-01

Receive Date

2023-11-01

Publish Date

2023-09-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_324267.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=324267

Order

10

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Evaluation of Effects of Antiepileptic Drugs on Pulmonary Functions in Children with Idiopathic Epilepsy Attending Neurology Outpatient Clinic in the National Institute of Neurom

Details

Type

Article

Created At

24 Dec 2024