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341641

The Neurobehavioral Effect of Ketogenic Diet on Cognitive Functions in Chronic Unpredictable Stress Adult Male Rat Model

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Last updated: 24 Dec 2024

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Basic Research

Abstract

Background: The ketogenic diet (KD) is a high-fat diet in which fatty acids become an obligatory energy source for the brain. Stressful events lead to structural and functional disturbances in the hippocampus and dentate cells responsible for memory. Aim: This work aimed to study how the KD modulates the effect of chronic unpredictable stress (CUS) on cognition via the modulation of the adult hippocampal and dentate neuronal cell neurogenesis in adult male rats. Materials and Methods:For this study; Twenty-four adult male Wistar albino rats, were divided into the Control group, normally fed palatable diet (NPD); KD group, fed on KD; CUS group, rat model fed on NPD, (CUS/NPD); CUS model group, fed on KD (CUS/KD) for 37 days. Barnes Maze (BM) assessed spatial memory and learning. Elevated plus maze (EPM) and open field test evaluated the anxiety-like behavior from CUS. To evaluate the KD effect, serum levels of ACTH, corticosterone, and brain homogenate of brain-derived neurotrophic factor (BDNF), dopamine, and acetylcholine (ACh). Results:CUS/KD group showed a reduction in the number of errors and latency time in BM. CUS/KD reduced the anxiety level compared to CUS. The same results were shown for brain neurotransmitters, antioxidant effect, and hormonal levels. For the hippocampus and dentate microstructure, CUS/KD showed an increase of neurogenesis doublecortin stain and restoration of the hippocampus and dentate neuronal cells. Conclusions: KD improved hippocampal neurogenesis and adverse stress effects on cognition, memory, and learning via decreasing anxiety and stress hormones and by increasing ACh, antioxidant effect, and BDNF.
 

DOI

10.21608/scumj.2023.341641

Keywords

Ketogenic diet, Stress, neurogenesis, Spatial Learning and Memory, Impairment

Authors

First Name

Lamis M.

Last Name

Asran

MiddleName

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Affiliation

Department of Human Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

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Orcid

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First Name

Samy

Last Name

Makary

MiddleName

-

Affiliation

Department of Human Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

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Orcid

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First Name

Horeya E.

Last Name

Korayem

MiddleName

-

Affiliation

Department of Histology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

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First Name

Eman

Last Name

Kolieb

MiddleName

-

Affiliation

Department of Human Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

eman.kolieb@yahoo.com

City

-

Orcid

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Volume

26

Article Issue

9

Related Issue

44148

Issue Date

2023-09-01

Receive Date

2024-02-16

Publish Date

2023-09-01

Page Start

75

Page End

86

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 26_Issue 9_Pages 75-86.pdf

PDF . 854.6kB

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https://scumj.journals.ekb.eg/article_341641.html

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https://scumj.journals.ekb.eg/service?article_code=341641

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

The Neurobehavioral Effect of Ketogenic Diet on Cognitive Functions in Chronic Unpredictable Stress Adult Male Rat Model

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Article

Created At

24 Dec 2024