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353814

Assessment of Immunohistochemical Expression of Androgen Receptor and its Correlation with Histopathological Prognostic Factors in Prostatic Carcinoma

Article

Last updated: 24 Dec 2024

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Basic Research

Abstract

Background: Prostate carcinoma (PCa) is the second most commonly diagnosed tumor in men worldwide and is the most common male malignancy in developed countries. Androgens play a main role in the growth, differentiation, and maintenance of prostate tissue via Androgen Receptor (AR). AR expression represents a potential prognostic marker for prostatic carcinoma. Aim: this study aims to assess of immunohistochemical expression of the Androgen receptor and its correlation with histopathological prognostic factors in Prostatic carcinoma. Methods: A cross-section analytical study was conducted at the pathology department of the Faculty of Medicine at Suez Canal University. Thirty-five prostatic specimens with prostate cancer were analyzed for immunohistochemichal expression of the Androgen receptor [AR (A19611)]. Results: Out of the studied thirty-five specimens. There is a statistically significant difference between different grade groups regarding AR expression (P value =0.008) & there is a statistically significant difference between different Gleason scores regarding AR expression (P value =0.001). There is no statistically significant difference between AR expression and Age of patients, Perineural invasion, multicenticity, and no benign prostatic changes. Conclusions: This study focused on evaluating the relationship of Androgen Receptor expression with various prognostic factors associated with carcinoma prostate, AR was upregulated in prostate cancer; mainly in cancers with a worse prognosis which has a higher Gleason Score and higher-grade group.
 

DOI

10.21608/scumj.2023.353814

Keywords

Androgen receptor, Immunohistochemistry, Prostatic adenocarcinoma

Authors

First Name

Radwa A.

Last Name

Ismail

MiddleName

-

Affiliation

Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

radwaalhousiny@med.suez.edu.eg

City

-

Orcid

-

First Name

Amr AM

Last Name

Kamel

MiddleName

-

Affiliation

Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed KE.

Last Name

Kherbetawy

MiddleName

-

Affiliation

Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

Volume

26

Article Issue

10

Related Issue

43656

Issue Date

2023-10-01

Receive Date

2024-05-09

Publish Date

2023-10-01

Page Start

26

Page End

34

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 26_Issue 10_Pages 26-34.pdf

PDF . 415.3kB

Link

https://scumj.journals.ekb.eg/article_353814.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=353814

Order

4

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Assessment of Immunohistochemical Expression of Androgen Receptor and its Correlation with Histopathological Prognostic Factors in Prostatic Carcinoma

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Article

Created At

24 Dec 2024