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322603

Role of Bone Marrow-Derived Mesenchymal Stem Cells in Healing of Femoral Bone Defect in Rat Model: Behavioral Psychomotor Performance, Oxidative-inflammatory Markers, Osteoblast

Article

Last updated: 24 Dec 2024

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Basic Research

Abstract

Background: Various techniques have been used to restore large bone abnormalities, but they have limitations. Mesenchymal stem cells (MSCs) have the potential to differentiate into bone tissue and are a promising candidate for cell therapy. Aim: This study aimed to investigate the effectiveness of using bone marrow-derived mesenchymal stem cells (MSCs) to treat femoral bone defects in rats. Material and Methods: The study was carried out in the Faculty of Medicine, Suez Canal University. The study involved dividing 27 male rats into control, defect, and stem cell-treated groups. The rats' locomotor activity, oxidative stress, inflammatory markers [tumor necrosing factor (TNF-α) and interleukin (IL-6)], angiogenic markers, osteoblast markers [Osteopontin and transforming growth factor (TGF-β)], and bone healing were assessed through various tests and measurements (histologically and radiologically). Results: The stem cell-treated group exhibited significantly improved locomotor activity, levels of inflammatory markers, total antioxidant capacity, and osteoblast markers compared to the defect group. Histological and radiological assessments indicated improvements in the stem cell-treated group. Conclusion: bone marrow-derived MSCs can enhance experimental bone healing by modulating oxidative stress, and inflammatory and angiogenic markers leading to improved locomotor parameters.
 

DOI

10.21608/scumj.2023.322603

Keywords

bone healing, bone marrow-derived mesenchymal stem cells, total antioxidant, Osteopontin, transforming growth factor-beta

Authors

First Name

Fatma A.

Last Name

Lotfy

MiddleName

-

Affiliation

Department of Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

First Name

Rasha

Last Name

Atta

MiddleName

-

Affiliation

Department of Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

rasha_atta@med.suez.edu.eg

City

ismailia

Orcid

https://orcid.org/00

First Name

Mohamed K.

Last Name

El-Kherbetawy

MiddleName

-

Affiliation

Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

First Name

Dalia

Last Name

Ibrahim

MiddleName

-

Affiliation

Department of Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

Volume

26

Article Issue

8

Related Issue

43654

Issue Date

2023-08-01

Receive Date

2023-10-23

Publish Date

2023-08-01

Page Start

1

Page End

15

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 26_Issue 8_Pages 1-15.pdf

PDF . 696.8kB

Link

https://scumj.journals.ekb.eg/article_322603.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=322603

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Role of Bone Marrow-Derived Mesenchymal Stem Cells in Healing of Femoral Bone Defect in Rat Model: Behavioral Psychomotor Performance, Oxidative-inflammatory Markers, Osteoblast Markers and Mesenchymal Stem Cell Growth Factors.

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Article

Created At

24 Dec 2024