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309500

Role of Serum Prolactin in Differentiating Tonic Clonic from Psychogenic Non-Epileptic Seizures in Emergency Department-Suez Canal University Hospital

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Last updated: 24 Dec 2024

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Clinical Research (Medical)

Abstract

Background:As paroxysmal events resemble epileptic seizures but lack electroencephalogram correlation, psychogenic nonepileptic seizures are a type of conversion disease. Prolactin (PRL) is a polypeptide that lactotrophic cells secrete during epileptic seizures; prolactin release from hypothalamic stimulation may relate to the propagation of epileptic discharges. Aim:To assess the ability of serum levels of serum prolactin to differentiate between Generalized tonic-clonic seizures (GTCS) andPsychogenic nonepileptic seizures (PNES). Subjects and Methods:Twenty GTCS patients and twenty PNES patients who visited Suez Canal University Hospital were the subjects of our prospective cohort research. The ABCDE technique was used to clinically evaluate and manage patients. Each patient underwent an initial evaluation that considered their medical history, clinical examination, laboratory investigation, and radiographic evaluation. Blood samples of serum PRL were taken from patients in both groups two hours after the event and 24 hours later. Results: The current study found statistically significant older age with psychogenic non-epileptic seizures compared to GTCS with p-value=0.037, while there was no gender difference between both groups, no statistically significant difference was found between GTCS and PNES as regards serum Na and K levels with p-value >0.05, 75% of patients with GTCS had positive EEG findings while only 10% of PNES had positive EEG findings. Serum PRL was significantly higher among GTCS than PNES with p-value Conclusion: Generalized tonic colonic seizures and psychogenic non-epileptic seizures can be distinguished using serum prolactin.
 

DOI

10.21608/scumj.2023.309500

Keywords

Video electroencephalography, reflex

Authors

First Name

Maria A.

Last Name

Kamel

MiddleName

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Affiliation

Department of Emergency Medicine, Faculty of Medicine-Suez Canal University, Egypt

Email

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Orcid

-

First Name

Mohamed E.

Last Name

Negm

MiddleName

-

Affiliation

Department of Neurology, Faculty of Medicine-Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Nashwa M.

Last Name

Abdelgeleel

MiddleName

-

Affiliation

Department of Emergency Medicine, Faculty of Medicine-Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Rasha M.

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Emergency Medicine, Faculty of Medicine-Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Khaled M.

Last Name

Salama

MiddleName

-

Affiliation

Department of Emergency Medicine, Faculty of Medicine-Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

26

Article Issue

7

Related Issue

42539

Issue Date

2023-07-01

Receive Date

2023-07-24

Publish Date

2023-07-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_309500.html

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https://scumj.journals.ekb.eg/service?article_code=309500

Order

8

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Role of Serum Prolactin in Differentiating Tonic Clonic from Psychogenic Non-Epileptic Seizures in Emergency Department-Suez Canal University Hospital

Details

Type

Article

Created At

24 Dec 2024