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309145

Molecular and Epigenetic Markers Correlation with Ultrasound Features of Breast Cancer

Article

Last updated: 24 Dec 2024

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Basic Research

Abstract

Background: Breast cancer is a complex disease with a wide range of clinical characteristics, histologic subtypes, treatment options, and prognoses. Breast imaging shows different tumor morphologies due to the diverse biology and histology of breast cancer. The correlation between morphological characteristics, molecular, and epigenetic markers in breast cancer evaluation has been examined in a few studies. Aim: to evaluate the correlation between ultrasound features, molecular and epigenetic markers in breast cancer cases. Subjects and Methods: A total of 115 women (80 cases and 35 controls) with BIRAD 4 Category breast lesions were included. The associations between the ultrasound features and molecular as well as epigenetic markers were evaluated. Results: The molecular markers were significantly correlated with posterior features of the lesion by ultrasound. Despite the significant correlation between the ITGB1 gene expression FC of the cases and that of the controls, ITGB1 gene expression FC was not significantly correlated with ultrasound features. Conclusion:Some ultrasound features can predict the molecular subtype of breast cancer. However, it can't be correlated with the levels of Linc-ITGB1 gene expression.
 

DOI

10.21608/scumj.2023.309145

Keywords

breast cancer, Ultrasound, molecular subtypes

Authors

First Name

Aya Sh.

Last Name

El-Rawy

MiddleName

-

Affiliation

Department of Radiology, Faculty of Medicine, Suez Canal University, Egypt

Email

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-

Orcid

-

First Name

Hoda Y.

Last Name

Abdallah

MiddleName

-

Affiliation

Medical Genetics Unit, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Marwa A.

Last Name

Soliman

MiddleName

-

Affiliation

Department of Oncology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohammed R.

Last Name

Habba

MiddleName

-

Affiliation

Department of Radiology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Azza A.

Last Name

Gad

MiddleName

-

Affiliation

Department of Radiology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

26

Article Issue

7

Related Issue

42539

Issue Date

2023-07-01

Receive Date

2023-07-20

Publish Date

2023-07-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_309145.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=309145

Order

6

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Molecular and Epigenetic Markers Correlation with Ultrasound Features of Breast Cancer

Details

Type

Article

Created At

24 Dec 2024