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309138

Comparing the Therapeutic Efficacy of Intradermal Injection of Platelet-Rich Plasma and Topical Application of Hydroquinone 2% in Melasma Treatment

Article

Last updated: 24 Dec 2024

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Tags

Clinical Research (Medical)

Abstract

Background: Melasma is a condition that causes the skin to get darker over time. There have been several therapies for melasma that have had mixed effects. Objective: To compare two therapeutic modalities for melasma; topical hydroquinone 2 percent and intradermal injection of PRP. Methods: Acase-control study of 60 mixed melasma female patients with Fitzpatrick skin types II, III, and IV was conducted. The patients were then separated into two groups: group (1) was treated with intradermal PRP injections for four sessions every three weeks, while Group (2) was treated with topical hydroquinone 2 percent for nine weeks. The % decrease in baseline MASI score and digital photography were used to evaluate the results. Results: MASI score was calculated at (0, 3, 6, 9 weeks) and after the last session by one month. PRP group and the Hydroquinone group were significantly different regarding the changes in the mean score of MASI score at week 13 of the study (P = 0.002). The mean MASI score was reduced by 54.79% in the PRP group and 24.52% in the hydroquinone group at week 13. Conclusion: Melasma may benefit from the use of platelet-rich plasma as an alternative therapy.
 

DOI

10.21608/scumj.2023.309138

Keywords

Melasma, platelet-rich plasma, Hydroquinone

Authors

First Name

Hesham A.

Last Name

Nada

MiddleName

-

Affiliation

Department of Dermatology, Venerology, and Andrology, Faculty of Medicine, Suez Canal University, Egypt

Email

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City

-

Orcid

-

First Name

Nader A.

Last Name

Ismail

MiddleName

-

Affiliation

Department of Dermatology, Venerology, and Andrology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Shaymaa A.

Last Name

Abd El Hady

MiddleName

-

Affiliation

Department Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Aya F.

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Dermatology, Ismailia Health Directorate, Egypt

Email

drayafouad91@gmail.com

City

Ismailia

Orcid

-

Volume

26

Article Issue

7

Related Issue

42539

Issue Date

2023-07-01

Receive Date

2023-07-20

Publish Date

2023-07-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_309138.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=309138

Order

5

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Comparing the Therapeutic Efficacy of Intradermal Injection of Platelet-Rich Plasma and Topical Application of Hydroquinone 2% in Melasma Treatment

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Type

Article

Created At

24 Dec 2024