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Osteoprotegerin Gene Polymorphism and Carotid Atherosclerosis

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Last updated: 04 Jan 2025

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Clinical Research (Medical)

Abstract

Background: Osteoprotegerin (OPG) was found to be a member of the TNF receptor superfamily. Substantial studies indicate that OPG abnormality is associated with cardiovascular and cerebrovascular disease. Objective: to find out the relationship between Osteoprotegerin (OPG) polymorphism and the occurrence of carotid atherosclerosis in ischemic stroke patients.Subjects and Methods: A case-control study was conducted on 50 patients and 50 controls, aged 49-64 years old, patients are diagnosed with ischemic stroke, and recruited from the neuropsychiatry department of Suez Canal university hospital. The OPG rs3102735 gene polymorphism was examined by polymerase chain reaction and restriction fragment length polymorphism, while the status of carotid arteries was studied by high-resolution B-mode ultrasonography.Results: The CC + CT genotypes and allele C frequencies of the rs3102735 gene polymorphism were significantly higher in the stroke patients than in the control group (98% vs. 86%, P = 0.04). We found no significant difference between Osteoprotegerin (OPG) rs3102735 polymorphism in patients regarding plaque morphology, stability, or stenosis degree (P value >0.05). Conclusion: no significant difference between OPG rs3102735 genetic variants and carotid atherosclerosis severity.
 

DOI

10.21608/scumj.2023.309040

Keywords

TNF receptor, Ischemic stroke, genotypes

Authors

First Name

Dina

Last Name

Mounir

MiddleName

-

Affiliation

Department of Neuropsychiatry, Faculty of Medicine, Suez Canal University

Email

dina.monir@med.suez.edu.eg

City

-

Orcid

0000-0002-2332-5241

First Name

Mohamed I.

Last Name

Negm

MiddleName

-

Affiliation

Department of Neuropsychiatry, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Mohamed A.

Last Name

Saad

MiddleName

-

Affiliation

Department of Neuropsychiatry, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Ahmed O.

Last Name

Hosny

MiddleName

-

Affiliation

Department of Neuropsychiatry, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Reda A.

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Neuropsychiatry, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

Volume

26

Article Issue

6

Related Issue

42520

Issue Date

2023-06-01

Receive Date

2023-07-19

Publish Date

2023-06-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_309040.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=309040

Order

10

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Osteoprotegerin Gene Polymorphism and Carotid Atherosclerosis

Details

Type

Article

Created At

24 Dec 2024