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309035

Relation between Osteoprotegerin Serum Level and Carotid Atherosclerosis

Article

Last updated: 24 Dec 2024

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Tags

Clinical Research (Medical)

Abstract

Background: Osteoprotegerin (OPG) is a member of the TNF receptor superfamily. Substantial studies indicate that OPG abnormality is associated with cardiovascular and cerebrovascular disease Objective: to find out the relationship between Osteoprotegerin (OPG) plasma level and the occurrence of carotid atherosclerosis in ischemic stroke patients. Subjects and Methods: A case-control study was conducted on 50 patients and 50 controls, aged 49-64 years old, patients are diagnosed with ischemic stroke, and recruited from the neuropsychiatry department of Suez Canal university hospital. The plasma OPG serum level was measured by ELISA technique and the status of carotid arteries was studied by high-resolution B-mode ultrasonography. Results: we found a weak positive not statically significant linear correlation between Osteoprotegerin (OPG) serum level and carotid intima-media thickness (r=0.178, p=0.215). Plasma OPG concentrations were none significantly higher in unstable plaques. Conclusion: High serum OPG as an independent risk factor may contribute to the pathogenesis of atherothrombotic ischemic stroke.
 

DOI

10.21608/scumj.2023.309035

Keywords

TNF receptor superfamily, Ischemic stroke, atherothrombotic

Authors

First Name

Dina

Last Name

Mounir

MiddleName

-

Affiliation

Department of Neuropsychiatry, Faculty of Medicine, Suez Canal University, Egypt

Email

dina.monir@med.suez.edu.eg

City

-

Orcid

0000-0002-2332-5241

First Name

Mohamed I.

Last Name

Negm

MiddleName

-

Affiliation

Department of Neuropsychiatry, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed A.

Last Name

Saad

MiddleName

-

Affiliation

Department of Neuropsychiatry, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed O.

Last Name

Hosny

MiddleName

-

Affiliation

Department of Neuropsychiatry, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Reda A.

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Neuropsychiatry, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

26

Article Issue

6

Related Issue

42520

Issue Date

2023-06-01

Receive Date

2023-07-19

Publish Date

2023-06-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_309035.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=309035

Order

9

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Relation between Osteoprotegerin Serum Level and Carotid Atherosclerosis

Details

Type

Article

Created At

24 Dec 2024