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308898

Assessment of Bone Health in Children with Nephrotic Syndrome Receiving Steroid Therapy

Article

Last updated: 24 Dec 2024

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Subjects

-

Tags

Clinical Research (Medical)

Abstract

Background: Nephrotic syndrome is a common kidney disease in pediatrics. Aim: to assess bone health in children with nephrotic syndrome by measuring the levels of serum vitamin D, calcium, and phosphorus in those children once the diagnosis is established and after 6 weeks of starting steroid therapy. Methods: We conducted a cohort study and included children with nephrotic syndrome attending the pediatric clinic or admitted at the inpatient, Suez Canal University, Ismailia, Egypt. Blood samples were collected, and serum calcium, phosphorus, alkaline phosphatase and vitamin D were measured at time of diagnosis and 6 weeks later. Results: We included 50 patients with nephrotic syndrome; 14 of them were newly diagnosed and 36 were relapsers. In both newly diagnosed and relapsers, all parameters dropped off after steroid therapy except for ALP which did not show significant affection in newly diagnosed patients. Vitamin D level dropped 7.6 ng/ml and 6.6 ng/ml in newly diagnosed and relapsers respectively after steroid therapy. Conclusions: Although steroids are the first line therapy for nephrotic syndrome in children, their long-term use is related to negative changes in bone health. Vitamin D supplementation is recommended in those patients to keep healthy and mineralized bones.
 

DOI

10.21608/scumj.2023.308898

Keywords

NS, bone minerals, Corticosteroids

Authors

First Name

Yomna M.

Last Name

Hassan

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Alaa

Last Name

Zeitoun

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Shaymaa

Last Name

Abdelraheem

MiddleName

-

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdelrahman

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt

Email

drahmedkotb1@gmail.com

City

-

Orcid

-

Volume

26

Article Issue

6

Related Issue

42520

Issue Date

2023-06-01

Receive Date

2023-07-19

Publish Date

2023-06-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_308898.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=308898

Order

8

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Assessment of Bone Health in Children with Nephrotic Syndrome Receiving Steroid Therapy

Details

Type

Article

Created At

24 Dec 2024