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308792

Induction Chemotherapy Followed by Concurrent Chemoradiation versus Concurrent Chemoradiation alone For Locally Advanced Laryngeal & Nasopharyngeal Cancers: A Retrospective Study

Article

Last updated: 24 Dec 2024

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Clinical Research (Medical)

Abstract

Background: Head and neck cancers are the sixth most common malignancy in the world, with unacceptably high mortality rates in developing countries. More than 90% of these cancers are squamous cell carcinomas (SCCs) and variants, originating from the epithelium of the mucosal lining of the upper aerodigestive tract. Aim: To evaluate the role of induction chemotherapy before concurrent chemoradiotherapy in the treatment of locally advanced non-metastatic (stage III or IV A, B) squamous cell carcinoma of laryngeal & nasopharyngeal cancers regarding progression-free survival, disease-free survival, toxicity, and organ preservation (laryngeal cancer). Patients and Methods: This is a retrospective study was conducted to estimate the value of induction chemotherapy followed by concurrent chemoradiation for locally advanced non-metastatic (stage III or IVA, B) squamous cell carcinoma of larynx & nasopharynx patients, attending Clinical Oncology Department, Suez Canal University Hospital, Ismailia, Egypt during the period from 1/2017 to 12\2018 &follow up period from 1/2019 to 12/2020. Results: This study revealed that there was no statistical significance in disease-free survival between the two groups. Regarding progression-free survival, there was a statistically significant in the Induction Chemotherapy followed by chemoradiotherapy, compared to chemoradiotherapy alone. Conclusion: Induction chemotherapy by TPF or PF is a reasonable approach for locally advanced non-metastatic nasopharyngeal and laryngeal squamous cell carcinoma as it gives better results in post-radiotherapy assessment for laryngeal cancers, and progression-free survival for both laryngeal and nasopharyngeal cancer patients.
 

DOI

10.21608/scumj.2023.308792

Keywords

Squamous Cell Carcinomas, concurrent chemoradiation, Laryngeal & Nasopharyngeal Cancers

Authors

First Name

Walaa S.

Last Name

Ali

MiddleName

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Affiliation

Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Ehab M.

Last Name

Hasanin

MiddleName

-

Affiliation

Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Maha L.

Last Name

Zamzam

MiddleName

-

Affiliation

Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Sharehan H.

Last Name

Soliman

MiddleName

-

Affiliation

Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

Volume

26

Article Issue

6

Related Issue

42520

Issue Date

2023-06-01

Receive Date

2023-07-18

Publish Date

2023-06-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_308792.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=308792

Order

6

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Induction Chemotherapy Followed by Concurrent Chemoradiation versus Concurrent Chemoradiation alone For Locally Advanced Laryngeal & Nasopharyngeal Cancers: A Retrospective Study

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Article

Created At

24 Dec 2024