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308880

Comparison of Survival Rate of Triple Negative versus Luminal B HER2 neu-positive Breast Cancer Patients in Oncology Medicine Center in Suez Canal University Hospital

Article

Last updated: 24 Dec 2024

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Tags

Clinical Research (Medical)

Abstract

Background: Triple-negative breast cancer (TNBC) and Triple-positive breast cancer (TPBC) pose a greater likelihood to recur both locally, regionally, and metastatically affecting patients' survival. Aim: To compare clinicopathological differences between TNBC and TPBC and assess possible associations of the parameters with recurrence and survival. Methods: Retrospective cohort study, medical records present at the Clinical Oncology and Nuclear medicine department SCUH between January 2010 till December 2018 were used to compare clinicopathological variables and DFS between both groups. Results: Hundred breast cancer patients, fifty in each group. There was significant difference regarding tumor stage (T) where 74% of TNBC had T2 stage and 44% of TPBC. 88% of TNBC had IDC compared to 68% of TPBC. Liver metastasis was the most common site in both groups followed by bone and lung. Three-year DFS was 73.5% and 77.5% in TNBC and TPBC respectively. Seven-year DFS was higher in patients with TNBC (60.5%) than in patients with TPBC (45%) but wasn't statistically significant. Regression analysis showed that patients without LVI had significantly 2.6 year higher in DFS time than patients with LVI in TNBC group. Conclusion: Diabetes and hypertension were the most reported comorbidities in both groups. There were significant differences regarding IDC, ENE, LVI, and PNI. Though there was no significant difference between both groups regarding the net disease progression. However, LVI was found to have a significant impact on this progression in each group separately.
 

DOI

10.21608/scumj.2023.308880

Keywords

breast cancer, TPBC, TNBC, Clinicopathological, DFS

Authors

First Name

Mai

Last Name

Mandor

MiddleName

M.

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

maimandour@med.suez.edu.eg

City

-

Orcid

-

First Name

Mahinour M.

Last Name

Atef

MiddleName

-

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Fifi M.

Last Name

El-Sayed

MiddleName

-

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Soheir E.

Last Name

Abdel-Mohsen

MiddleName

-

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

26

Article Issue

6

Related Issue

42520

Issue Date

2023-06-01

Receive Date

2023-07-19

Publish Date

2023-06-01

Page Start

20

Page End

31

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 26_Issue 6_Pages 20-31.pdf

PDF . 420.0kB

Link

https://scumj.journals.ekb.eg/article_308880.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=308880

Order

3

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Comparison of Survival Rate of Triple Negative versus Luminal B HER2 neu-positive Breast Cancer Patients in Oncology Medicine Center in Suez Canal University Hospital

Details

Type

Article

Created At

24 Dec 2024