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308712

Effect of Rheumatoid Arthritis Disease Activity on Left Ventricular Function

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Last updated: 24 Dec 2024

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Clinical Research (Medical)

Abstract

Background: Rheumatoid arthritis (RA) is a debilitating disease characterized by chronic symmetric polyarthritis involving peripheral small joints causing deformities, severe disability and premature mortality. Aim: evaluation of the subclinical LVSD by using Speckled Echocardiography in RA patients according to the activity of the disease. Subjects and Methods: A comparative study was carried out to detect the effect of RA disease activity on Lt. ventricular motion using Speckled Echocardiography. This study was carried out at the Physical Medicine, Rheumatology, and Rehabilitation department of Suez Canal University and Ismailia General Hospitals. The study population was patients with rheumatoid arthritis attending the Physical Medicine, Rheumatology, and Rehabilitation departments of Suez Canal University and Ismailia General Hospitals. Result:Smoking showed statistically significant differences between the two groups (p=0.003). The disease activity was more severe among group A with statistically significant differences (p < 0.001).Group A had significantly higher mean ESR and CRP than group B. GLSs in group A were significantly lower than in group B: 16.7±2.6 vs. 19.1±2.4 % (p = 0.012). GLS showed statistically significant negative moderate correlations with disease duration, DAS 28 score ESR, DAS 28 score CRP and significant negative weak correlation with the tender joint. Duration of rheumatoid disease, DAS28-CRP, and DAS28-ESR score were significantly associated with lower values of GLSs. Conclusion: RA patients with high DAS and no clinical CVD have lower LV systolic function than RA with low DAS. Serial GLSs measurement is considered as a long-term follow-up tool in these patients.
 

DOI

10.21608/scumj.2023.308712

Keywords

Rheumatoid Arthritis, GLS and Echocardiography

Authors

First Name

Ahlam A.

Last Name

Ismail

MiddleName

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Affiliation

Department of Physical Medicine, Rheumatology, and Rehabilitation, ¹Ismailia General Hospital, Egypt

Email

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City

-

Orcid

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First Name

Mai M.

Last Name

Abdelnaby

MiddleName

-

Affiliation

Department of Physical Medicine, Rheumatology, and Rehabilitation, Faculty of Medicine, Suez Canal University, Egypt

Email

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City

-

Orcid

-

First Name

Mohamed Y.

Last Name

Saber

MiddleName

-

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed T.

Last Name

Abdel-lah

MiddleName

-

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Samah I.

Last Name

Nasef

MiddleName

-

Affiliation

Department of Physical Medicine, Rheumatology, and Rehabilitation, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

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Volume

26

Article Issue

5

Related Issue

42291

Issue Date

2023-05-01

Receive Date

2023-07-18

Publish Date

2023-05-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_308712.html

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https://scumj.journals.ekb.eg/service?article_code=308712

Order

12

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Effect of Rheumatoid Arthritis Disease Activity on Left Ventricular Function

Details

Type

Article

Created At

24 Dec 2024