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306914

Pattern of Serum Osteopontin Level in Patients with Cirrhotic Liver versus Patients with Hepatocellular Carcinoma

Article

Last updated: 24 Dec 2024

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Tags

Clinical Research (Medical)

Abstract

Background:The overall prognosis of HCC is generally poor, mostly due to the difficulties of early diagnosis. Therefore, it's very important to identify new, highly sensitive, and specific markers for HCC to enhance the early detection rate and improve treatment effects. Several reports have proposed a valuable role for osteopontin (OPN) as a promising biomarker for early diagnosis of HCC. Aim:To evaluate the pattern of OPN in Egyptian HCC patients versus cirrhotic patients. Subjects and Methods:This comparative study was conducted at the Internal Medicine department in Suez Canal University (SCU) hospital, Ismailia, Egypt. Ninety individuals were enrolled in our study and assigned into three groups. The HCC group included 40 patients with HCC, the cirrhotic group included 40 patients diagnosed with liver cirrhosis mostly due to HCV, and the control group included 10 apparently healthy individuals. We compared AFP and OPN levels between the three groups. Results: Mean serum OPN and AFP levels were significantly higher among HCC patients, compared to cirrhotic patients and the controls (P<0.001). Moreover, OPN was positively correlated with AFP (P<0.001) and bilirubin level (P<0.001), whereas it was negatively correlated with albumin level (P<0.001). Meanwhile, OPN was not significantly correlated with AST or ALT (P= 0.061 and 0.102, respectively). Conclusion:OPN level is significantly elevated in HCC and cirrhotic patients, and it's positively correlated with AFP and bilirubin, and negatively correlated with albumin levels. In HCC patients particularly, OPN levels decrease significantly after treatment.
 

DOI

10.21608/scumj.2023.306914

Keywords

Cirrhosis, alpha-fetoprotein

Authors

First Name

Mohamed Y.

Last Name

El-shafaey

MiddleName

-

Affiliation

Department of Internal Medicine, Port-Fouad General Hospital, Egypt

Email

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City

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Orcid

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First Name

Seham A.

Last Name

Omar

MiddleName

-

Affiliation

Department of Internal Medicine and Hepatology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Ayman S.

Last Name

Amer

MiddleName

-

Affiliation

Department of Internal Medicine and Hepatology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed M.

Last Name

El-shabrawy

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

26

Article Issue

5

Related Issue

42291

Issue Date

2023-05-01

Receive Date

2023-07-08

Publish Date

2023-05-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_306914.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=306914

Order

6

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Pattern of Serum Osteopontin Level in Patients with Cirrhotic Liver versus Patients with Hepatocellular Carcinoma

Details

Type

Article

Created At

24 Dec 2024