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306591

Mucoadhesive Gel as a Vehicle for Antibiotic Intranasal Delivery in Experimental Animals. Light and Transmission Electron Microscopy

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Last updated: 24 Dec 2024

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Clinical Research (Surgical)

Abstract

Background: Mucoadhesive nasal gel provides a good platform for drug delivery to the nasal mucosa. We aimedto detect the histologic effect of Mucoadhesive Gel as a Vehicle for Antibiotic Intranasal Delivery in Experiment Animals. Light and transmission electron microscopy. Methods:Thirty-six mature male rabbits were placed into three groups. Non-diseased subjects receive intranasal mucoadhesive gel in the vehicle control group. The non-diseased group received intranasal Neomycin-loaded mucoadhesive gel. The non-diseased group receives intranasal ciprofloxacin-loaded mucoadhesive gel. Toluidine blue was used to stain a section of the nasal mucosa for Light and transmission electron microscopy.Results:There is a statistically insignificant difference in histological changes between the Neomycin group and Ciprofloxacin group regarding ciliated, partially deciliated cells, Goblet cells, and variable stain (P.>0.05). Conclusion: Because the antibiotic-loaded mucoadhesive gel caused little harm while preserving the nasal mucosa's integrity, it might be deemed a safe vehicle for administering topical antibiotics.
 

DOI

10.21608/scumj.2023.306591

Keywords

mucoadhesive gel, Nanoparticles, antibiotics, nasal mucosa, histopathology

Authors

First Name

Amr S.

Last Name

Mohammed

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

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City

-

Orcid

-

First Name

Diaa Eldin M.

Last Name

ElHennawi

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed T.

Last Name

El-Tabbakh

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Omnia E.

Last Name

Kilany

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed R.

Last Name

Gardouh

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

26

Article Issue

4

Related Issue

42075

Issue Date

2023-04-01

Receive Date

2023-07-05

Publish Date

2023-04-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_306591.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=306591

Order

12

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Mucoadhesive Gel as a Vehicle for Antibiotic Intranasal Delivery in Experimental Animals. Light and Transmission Electron Microscopy

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Article

Created At

24 Dec 2024