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306587

Correlation between Plateletcrit and Hyperemesis Gravidarum among Pregnant Women in Suez Canal University Hospital

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Last updated: 04 Jan 2025

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Clinical Research (Medical)

Abstract

Background: Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting affecting 0.8-2.3% of pregnant women. Multiple pregnancy, hyperthyroidism, molar pregnancy, and diabetes are well-known risk factors of HG. Platelets modulate inflammatory reactions. Therefore, platelet indices, such as the platelet to lymphocyte ratio (PLR) and platelet crit (PCT) have been found to be associated with inflammatory diseases, No enough data are available evaluating the relationship between the PLR, PCT, and the presence and severity of HG. Aim: To predict the severity of HG by measuring Plateletcrit in HG patients for early diagnosis and management and to improve their quality of life. Patients and Methods: In this cross-sectional study, 270 pregnant women diagnosed with HG were enrolled and divided into three groups according to the severity of HG: mild, moderate, and severe using a modified 24-hour PUQE score, and a Complete Blood Count was performed to all the study population. Results: Out of 270 HG patients, those with moderate/severe HG have higher levels of plateletcrit, platelet count, and acetone in urine compared to patients with the mild disease while there was no statistically significant difference between patients with moderate and severe disease. plateletcrit % > 0.22 is a significant predictor of the presence of moderate/severe HG with a sensitivity of 45% and 90% specificity. Plateletcrit % > 0.19 is a significant predictor of the presence of HG with a sensitivity of 80% and 70% specificity. Plateletcrit was significantly lower in patients who developed relapse of emesis (0.17 ± SD 0.04% versus 0.21± SD 0.08%, p-0.006). In addition, the development of chronic hypertension (0.16 ± SD 0.08% versus 0.21± SD 0.08%, p=0.001). Patients who suffered from psychic trauma of emesis had lower plateletcrit (%) versus those who did not (0.17 ± SD 0.07% versus 0.21± SD 0.04%, p=0.001). Conclusion: Plateletcrit is a valuable marker in detecting HG, its severity, and the incidence of maternal and fetal complications. A cutoff point >0.2 is the most sensitive in detecting the presence of HG.
 

DOI

10.21608/scumj.2023.306587

Keywords

Hyperemesis gravidarum, Lymphocyte Ratio, Plateletcrit

Authors

First Name

Soha S.

Last Name

Kewan

MiddleName

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Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Egypt

Email

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City

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Orcid

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First Name

Elham H.

Last Name

Madany

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Tamer Y.

Last Name

Mohammed

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed A.

Last Name

Elbahii

MiddleName

-

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

26

Article Issue

4

Related Issue

42075

Issue Date

2023-04-01

Receive Date

2023-07-05

Publish Date

2023-04-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_306587.html

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https://scumj.journals.ekb.eg/service?article_code=306587

Order

11

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Correlation between Plateletcrit and Hyperemesis Gravidarum among Pregnant Women in Suez Canal University Hospital

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Type

Article

Created At

24 Dec 2024