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306445

Histological Evaluation of Perforated Tympanic Membrane Repair Following the Use of Autologous Platelet Rich Fibrin: An Experimental Study

Article

Last updated: 24 Dec 2024

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Tags

Clinical Research (Surgical)

Abstract

Objective: An experimental study was conducted to determine the histological evaluation of perforated tympanic membrane repair following the use of autologous platelet-rich fibrin. Material and Methods: Forty-four dogs had significant central tympanic perforations (at least two quadrants) in their right ears and were followed for eight weeks before being randomly separated into two equal groups by lottery. PRF was utilized in the research group (A) to heal dry chronic tympanic perforation in dogs' right ears. PRF was not employed in group B; only the borders of the tympanic membrane perforation were trimmed. After 8 weeks, the closure of the perforated tympanic membrane with a platelet-rich fibrin membrane. stained with hematoxylin and eosin under a light microscope. was evaluated histopathologically for neovascularization, fibrosis, inflammation, and edema. Results: After 8 weeks, there was a statistically significant difference between the Study Group and the Control Group in terms of neovascularization, fibrosis, inflammation, and edema. Conclusion: PRF membrane can be utilized to repair tympanic membrane perforation and promote wound healing. This approach may become more popular in the future in a variety of fields since it is an autogenous material that is safe and effective, easy to use, and affordable in cost while not extending working time.    

DOI

10.21608/scumj.2023.306445

Keywords

Myringoplasty, perforated tympanic membrane, PRF

Authors

First Name

Samy M.

Last Name

El-Sayed

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Nagy M.

Last Name

Iskander

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Diaa ElDin M.

Last Name

ElHennawi

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Yasser T.

Last Name

Madian

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Alaa M.

Last Name

Farid

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

26

Article Issue

4

Related Issue

42075

Issue Date

2023-04-01

Receive Date

2023-07-04

Publish Date

2023-04-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_306445.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=306445

Order

10

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Histological Evaluation of Perforated Tympanic Membrane Repair Following the Use of Autologous Platelet Rich Fibrin: An Experimental Study

Details

Type

Article

Created At

24 Dec 2024