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Functional Capacity and Outcome of Auto-transplantation of Thyroid Gland Tissue after Total Thyroidectomy for Benign Thyroid Disease

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Last updated: 04 Jan 2025

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Clinical Research (Surgical)

Abstract

Background:Total thyroidectomy is the operation of choice today in the treatment of benign thyroid diseases affecting both lobes. When this operation is done precisely, the patients will survive safely with the lowest complications. Aim: The aim of this work was to solve the problems of patients undergoing total thyroidectomy for benign thyroid diseases. Also was to evaluate the survival and the functional capacity of auto-transplanted thyroid gland tissue after total thyroidectomy for benign thyroid disease. Patients and Methods: A prospective case study was conducted on 30 patients who were candidates for total thyroidectomy for benign thyroid disease followed by auto-transplantation of thyroid gland tissue in the thigh muscle, studying the outcome and functional capacity of the transplanted tissue. Results: Median TSH of studied patients showed a marked decrease from 1-month post operation till 12-month post-operation,after 12 months post-implantation, this study showed; 22 patients (73.3%) full functioning implant (i.e., normal thyroid function tests), 3 patients (10%) partial functioning implant and 5 patients (16.7%) failed implant (i.e., low T3 and T4 and very high TSH). Conclusion: Thyroid auto-transplantation is a promising technique that requires further study, as 73.3% of the patients in this study had fully functioning grafts at the end of the study. Body weight and operative time had no significant correlation with the grafts' functional outcome. Worse results were achieved in patients with Graves' disease compared with the patients with multinodular goiter. The young patients and the weight of the implanted tissue of 10 g had a good impact on the result of transplantation.

DOI

10.21608/scumj.2023.305531

Keywords

Auto-transplantation, Thyroidectomy, Outcome, Functional capacity, Complications

Authors

First Name

Osama A.

Last Name

Adly

MiddleName

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Affiliation

Plastic Surgery Unit, General Surgery Department, Faculty of Medicine, Suez Canal University, Egypt

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Orcid

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First Name

Mohammed A.

Last Name

El-Sayed

MiddleName

-

Affiliation

Department of General Surgery, Faculty of Medicine, Suez Canal University, Egypt

Email

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City

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Orcid

-

First Name

Mohammed S.

Last Name

Ibrahim

MiddleName

-

Affiliation

Pediatric Surgery Unit, General Surgery Department, Faculty of Medicine, Suez Canal University, Egypt

Email

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City

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Orcid

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First Name

Ahmed R.

Last Name

Shalaby

MiddleName

-

Affiliation

General Surgery Department, Mansoura New General Hospital, Egypt

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-

City

-

Orcid

-

Volume

26

Article Issue

4

Related Issue

42075

Issue Date

2023-04-01

Receive Date

2023-06-28

Publish Date

2023-04-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_305531.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=305531

Order

8

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Functional Capacity and Outcome of Auto-transplantation of Thyroid Gland Tissue after Total Thyroidectomy for Benign Thyroid Disease

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Article

Created At

24 Dec 2024