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Experimental Study for Preparation and Characterization of a Mucoadhesive Gel as a Vehicle for Intranasal Delivery of Topical Antibiotic Therapy

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Last updated: 24 Dec 2024

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Clinical Research (Medical)

Abstract

Background: Mucoadhesive nasal gel provides a good platform for drug delivery to the nasal mucosa. We aimedto detect the histologic effect of mucoadhesive-loaded antibiotics on the nasal mucosa of the rabbits by light microscope and scanning electron microscope to detect the ultra-structure changes.Materials and Methods:A total of 36 adult male rabbits were divided into 3 groups. Vehicle control group (A): Non-diseased, receives intranasal mucoadhesive gel. Group (B): Non-diseased, receives intranasal Neomycin-loaded mucoadhesive gel.Group (C): Non-diseased, receives intranasal ciprofloxacin-loaded mucoadhesive gel.Part of the nasal mucosa was stained by Toluidine blue for scanning light microscopy.The other part of the Nasal mucosa was immediately fixed in 1.5% glutaraldehyde in phosphate-buffered saline (pH 7.4) for 2 h at room temperature, and determination of morphological properties and microscopic ultra-structure was performed. Results:There is a statistically insignificant difference in histological changes in inflammatory cells of the Ciprofloxacin group also surface mucosa shows deciliation of a wide area of the epithelial cells andnasal mucosa shows necrobiosis of numerous epithelial cells. Congestion is significantly higher in the Neomycin group (46.1%) than in the Ciprofloxacin group (7.7%). Conclusion: Antibiotic-loaded mucoadhesive gel showed minimal damage with preserved integrity of the nasal mucosa, so it could be considered a safe vehicle for delivering topical antibiotics.
 

DOI

10.21608/scumj.2023.305530

Keywords

mucoadhesive gel, Nanoparticles, antibiotics, nasal mucosa, histopathology

Authors

First Name

Amr S.

Last Name

Mohammed

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

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City

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Orcid

-

First Name

Diaa ElDin M.

Last Name

ElHennawi

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed T.

Last Name

El-Tabbakh

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Omnia E.

Last Name

Kilany

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Ahmed R.

Last Name

Gardouh

MiddleName

-

Affiliation

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

26

Article Issue

4

Related Issue

42075

Issue Date

2023-04-01

Receive Date

2023-06-28

Publish Date

2023-04-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_305530.html

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https://scumj.journals.ekb.eg/service?article_code=305530

Order

7

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Experimental Study for Preparation and Characterization of a Mucoadhesive Gel as a Vehicle for Intranasal Delivery of Topical Antibiotic Therapy

Details

Type

Article

Created At

24 Dec 2024