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305076

Ganglion Cell Complex and Optical Coherence Tomography Angiography in Assessment of Early Diabetic Retinal Changes

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Last updated: 04 Jan 2025

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Clinical Research (Medical)

Abstract

Background: Diabetes mellitus is a chronic disorder of glucose metabolism that has serious clinical consequences including microvascular (retinopathy, nephropathy, neuropathy) and macrovascular (ischemic heart disease, stroke, peripheral vascular disease) complications. Diabetic retinopathy (DR) is a major cause of visual impairment worldwide in working-age individuals and is a micro-vascular complication. Aim and objectives: The aim of this study is to recognize the contributions of microvascular and neural changes in the pathogenesis of diabetic retinopathy. Patients and methods:We conduct a cross-sectional analytical study of 22 eyes of diabetic patients and 22 eyes of matched controls, evaluated for retinal neuro-degeneration and micro-vascular changes at the Ophthalmology outpatient clinic, Suez Canal University (SCU) Hospital, Ismailia using OCT and OCTA. Results: Micro-vascular changes in the diabetic group showed mean±SD of the s-FAZ was 452.80±193.0µm2,mean±SD d-FAZ was 717.71±233.13 µm2 and mean±SD of the foveal vessel density was 15.93±6.28%and in the control group showed mean±SD of s-FAZ was 285.40±68.65µm2, mean±SD of d-FAZ was 481.70±101.17µm2 and mean±SD of foveal vessel density was 20.33±3.10% and neurodegenerative changes showed mean±SD of macular GCL+ layer thickness for the diabetic group was 61.41±5.20µm while for the control group was 66.82±6.82µm and mean±SD of macular GCL++ layer thickness for the diabetic group was 98.73±7.64µm and for the control group was 106.41±11.59µm. Conclusion: Micro-vascular assessment in diabetic patients showed there is enlargement in s-FAZ and d-FAZ areas and their neural assessment showed there is thinning in the inner retinal layers, so there is a negative relationship between them.
 

DOI

10.21608/scumj.2023.305076

Keywords

diapetic retinopathy, microvascular, retinal neuro-degeneration

Authors

First Name

Ahmed

Last Name

Mourad

MiddleName

M.

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University Hospitals. Ismailia, Egypt.

Email

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City

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Orcid

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First Name

Hussein

Last Name

EL-Nahass

MiddleName

S.

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University Hospitals. Ismailia, Egypt.

Email

-

City

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Orcid

-

First Name

Mahmoud

Last Name

Ghonaim

MiddleName

A.

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University Hospitals. Ismailia, Egypt.

Email

mahmoudghonaim@med.suez.edu.eg

City

-

Orcid

-

Volume

26

Article Issue

3

Related Issue

41996

Issue Date

2023-03-01

Receive Date

2023-06-25

Publish Date

2023-03-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_305076.html

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https://scumj.journals.ekb.eg/service?article_code=305076

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11

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Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Ganglion Cell Complex and Optical Coherence Tomography Angiography in Assessment of Early Diabetic Retinal Changes

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Article

Created At

24 Dec 2024