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304782

Assessment of C-X-C Motif Chemokine Ligand 10 (CXCL10) Serum Level in Patients with Vitiligo

Article

Last updated: 24 Dec 2024

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Tags

Clinical Research (Medical)

Abstract

Background: Vitiligo is a common depigmentation disorder that affects 0.1% to 2% of the population. Patients with vitiligo have an increase in autoreactive CD8+ T cells that target melanocytes in their serum and skin, resulting in melanocyte cytotoxicity.CXCL10 chemokine binds the CXCR3 receptor expressed on T cells, monocytes, and natural killer cells inducing their tissue recruitment.CXCL10 plays a role in many autoimmune diseases. Aim: Evaluate CXCL10 serum level in patients with vitiligocompared to healthy controls and detect its correlation with the disease activity.Methods:In this case-control study, 20 vitiligo patients and 20 healthy controls were enrolled. An enzyme-linked immunosorbent assay was used to compare the serum level of CXCL10 in vitiligo patients to healthy controls (ELISA).Results: The level of CXCL10serum was noticeably higher in patients with vitiligo than in controls (p=0.021) and correlated positively with disease activity (VIDA) (p < 0.001).Conclusion:CXCL10 might have a role in the pathogenesis of vitiligo and might serve as a marker for disease activity.Further large-scale studies are needed to confirm the definite role of CXCL10 in vitiligo pathogenesis.
 

DOI

10.21608/scumj.2023.304782

Keywords

Vitiligo, Autoimmunity, CXCL10

Authors

First Name

Sahar

Last Name

Sleem

MiddleName

-

Affiliation

Department of Dermatology, Ministry of Health and Population, Faqous General Hospital, El Sharqia, Egypt

Email

-

City

-

Orcid

-

First Name

Radwa

Last Name

Marie

MiddleName

-

Affiliation

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Egypt.

Email

rivercruise84@gmail.com

City

-

Orcid

-

First Name

Noha

Last Name

Kamel

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

nohakamel18@gmail.com

City

-

Orcid

0000-0002-8990-2312

First Name

Mona

Last Name

Atwa

MiddleName

-

Affiliation

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Egypt.

Email

atwamona@gmail.com

City

-

Orcid

-

Volume

26

Article Issue

2

Related Issue

41115

Issue Date

2023-02-01

Receive Date

2023-06-22

Publish Date

2023-02-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_304782.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=304782

Order

11

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Assessment of C-X-C Motif Chemokine Ligand 10 (CXCL10) Serum Level in Patients with Vitiligo

Details

Type

Article

Created At

24 Dec 2024