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304694

Role of Serum Prolactin in Differentiating Tonic Clonic from Psychogenic Non-Epileptic Seizures in Emergency Department-Suez Canal University Hospital

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Last updated: 04 Jan 2025

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Abstract

Background:As paroxysmal events resemble epileptic seizures but lack electroencephalogram correlation, psychogenic nonepileptic seizures are a type of conversion disease. Prolactin (PRL) is a polypeptide that lactotrophic cells secrete during epileptic seizures; prolactin release from hypothalamic stimulation may be connected with the propagation of epileptic discharges.Aim:To assess the ability of serum levels of serum prolactin to differentiate between Generalized tonic-clonic seizures (GTCS) andPsychogenic nonepileptic seizures (PNES).Subjects and Methods:Twenty GTCS patients and twenty PNES patients who visited Suez Canal University Hospital were the subjects of our prospective cohort research. The ABCDE technique was used to clinically evaluate and manage patients. Each patient underwent an initial evaluation that took into account their medical history, clinical examination, laboratory investigation, and radiographic evaluation. Blood samples of serum PRL were taken from patients in both groups two hours after the event and 24 hours later.Results: The current study found statistically significant older age with psychogenic nonepileptic seizures compared to GTCS with p-value=0.037, while there was no gender difference between both groups, no statistically significant difference was found between GTCS and PNES as regards serum Na and K levels with p-value >0.05, 75% of patients with GTCS had positive EEG findings while only 10% of PNES had positive EEG findings. Serum PRL was significantly higher among GTCS than PNES with a p-value <0.001.Conclusion: Generalized tonic colonic seizures and psychogenic non-epileptic seizures can be distinguished using serum prolactin.  

DOI

10.21608/scumj.2023.304694

Keywords

Video electroencephalography, reflex

Authors

First Name

Maria

Last Name

Kamel

MiddleName

-

Affiliation

Department of Emergency Medicine, Faculty of Medicine-Suez Canal University.

Email

dr.maria.kamel@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Negm

MiddleName

-

Affiliation

Department of Neurology, Faculty of Medicine-Suez Canal University.

Email

mohnegm2@yahoo.com

City

-

Orcid

0000-0003-1477-0148

First Name

Nashwa

Last Name

Abdelgeleel

MiddleName

-

Affiliation

Department of Emergency Medicine, Faculty of Medicine-Suez Canal University.

Email

-

City

-

Orcid

-

First Name

Rasha

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Emergency Medicine, Faculty of Medicine-Suez Canal University.

Email

maloka2182@yahoo.com

City

-

Orcid

-

First Name

Khaled

Last Name

Salama

MiddleName

-

Affiliation

Department of Emergency Medicine, Faculty of Medicine-Suez Canal University.

Email

khaled_salama@med.suez.edu.eg

City

-

Orcid

0000-0002-22299088

Volume

26

Article Issue

2

Related Issue

41115

Issue Date

2023-02-01

Receive Date

2023-06-21

Publish Date

2023-02-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_304694.html

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https://scumj.journals.ekb.eg/service?article_code=304694

Order

10

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Role of Serum Prolactin in Differentiating Tonic Clonic from Psychogenic Non-Epileptic Seizures in Emergency Department-Suez Canal University Hospital

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Article

Created At

24 Dec 2024