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Assessment of Effectiveness of Maintenance Capecitabine among Triple Negative Breast Cancer Patients Attending Suez Canal University Hospital

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Last updated: 04 Jan 2025

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Clinical Research (Medical)

Abstract

Background: Triple Negative Breast Cancer (TNBC) accounts for approximately 15% of breast cancer cases. TNBC has a poor prognosis and worse survival. The addition of adjuvant capecitabine for TNBC with non-pathological complete response (non-PCR) after neoadjuvant chemotherapy (NACT) has been recommended in most guidelines. However, for those early TNBC patients without NACT the effectiveness of adding capecitabine is still controversial.Aim:To assess the effectiveness & and tolerability of maintenance Capecitabine among TNBC patients. Objectives:The primary objectives were to evaluate the tolerability and DFS of maintenance Capecitabine in TNBC patients in comparison to those who received the standard of care. Meanwhile, the Secondary Objective was to compare the OS. Patients and Methods:A randomized controlled two parallel groups study design was conducted among TNBC patients attending the Clinical Oncology and Nuclear Medicine Department at Suez Canal University Hospital during the period from January2019 to January 2022. A total of 120 patients were randomly allocated into control or intervention groups with 60 patients in each group. Patients in the intervention group received oral capecitabine at a dose of 500 mg BID monthly. Treatment continued for 2 years or until disease progression or emergence of intolerable toxicity. Kaplan-Meier method and log-rank test were used for survival analysis. Results:The mean age of patients was 46.5 years in the control group compared to 48.2 years in the Capecitabine group. In the Capecitabine group DFS significantly longer (76.7 %) than in the control group (30%), OS 90 % compared to 82.2 % in the control group. 23% of patients who received Capecitabine experienced adverse effects, the most frequent adverse effects were gastritis (17%) followed by dermatitis (3%), neuropathy (2%), and Hand-Foot syndrome (1%). Conclusion: Adjuvant maintenance capecitabine was well tolerated and efficacious in improving the DFS& and OS in TNBC.
 
 

DOI

10.21608/scumj.2023.320127

Keywords

DFS= disease-free survival OS: overall survival. IDC: infiltrating duct carcinoma, Capecitabine

Authors

First Name

Asmaa M.

Last Name

Fouad

MiddleName

-

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt.

Email

asmaafouad89.onco89@gmail.com

City

-

Orcid

-

First Name

Maha L.

Last Name

Zamzam

MiddleName

-

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Sohair E.

Last Name

Abd elmohsen

MiddleName

-

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Fifi M.

Last Name

Elsayed

MiddleName

-

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Marwa A.

Last Name

Suliman

MiddleName

-

Affiliation

Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

Volume

26

Article Issue

2

Related Issue

41115

Issue Date

2023-02-01

Receive Date

2023-10-05

Publish Date

2023-02-01

Page Start

46

Page End

54

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 26_Issue 2_Pages 46-54.pdf

PDF . 394.1kB

Link

https://scumj.journals.ekb.eg/article_320127.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=320127

Order

6

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Assessment of Effectiveness of Maintenance Capecitabine among Triple Negative Breast Cancer Patients Attending Suez Canal University Hospital

Details

Type

Article

Created At

24 Dec 2024