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300569

Association between Urinary Cyclophilin A and Diabetic Nephropathy in Children with Type 1 Diabetes Mellitus

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical Research (Medical)

Abstract

Background: Diabetes is a group of metabolic diseases marked by hyperglycemia caused by insulin secretion, action, or both. Diabetes chronic hyperglycemia is associated with long-term damage, dysfunction, & failure of numerous organs, most notably eyes, kidneys, nerves, heart, & blood vessels. Aim and objectives: This research aimed to evaluate the association between Urinary Cyclophilin A & diabetic nephropathy in children& adolescents with Type 1 Diabetes Mellitus (T1DM). Subjects and Methods: Sixty children& adolescents were recruited consecutively from those attending diabetes outstudied case clinic in Suez Canal University Children's Hospital. Thirty years old & gender-matched children & adolescents were recruited as the control group. Results: Concerning urinary CyPA, we found that those with microalbuminuria had the highest urinary CyPA levels when compared to others. This was statistically significant (p < 0.001). On performing post hoc analysis, we found that variation could be explained by the difference among group B included normoalbuminuric diabetic children and adolescents and group C included healthy children and adolescents (p < 0.001), among group A included microalbuminuric diabetic children and adolescents &group C (p < 0.001). Conclusion: Urinary CyPA can be used as an early indicator for Diabetic nephropathy because important great levels of urinary CyPA were detected in T1DM studied cases with DN before the presence of albuminuria.
 

DOI

10.21608/scumj.2023.300569

Keywords

diabetes, juvenile, Cyclophyllin A, relationship

Authors

First Name

Dina

Last Name

Khamis

MiddleName

F.

Affiliation

Neonatology Unit, MetGhamr Central Hospital, Egypt

Email

faroukdina718@gmail.com

City

Tanta

Orcid

-

First Name

Amina

Last Name

Abdel Wahab

MiddleName

M.

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Hanan

Last Name

Omar

MiddleName

H.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

hananhassan1978@gmail.com

City

-

Orcid

-

First Name

Zeinab

Last Name

Mohammed

MiddleName

A.

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

26

Article Issue

2

Related Issue

41115

Issue Date

2023-02-01

Receive Date

2023-05-27

Publish Date

2023-02-01

Page Start

25

Page End

34

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 26_Issue 2_Pages 25-34.pdf

PDF . 343.6kB

Link

https://scumj.journals.ekb.eg/article_300569.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=300569

Order

4

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Association between Urinary Cyclophilin A and Diabetic Nephropathy in Children with Type 1 Diabetes Mellitus

Details

Type

Article

Created At

24 Dec 2024