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299510

Correlation between Degree of Asthma Severity and Malondialdehyde in Asthmatic Children in Ismailia

Article

Last updated: 24 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Clinical Research (Medical)

Abstract

Background: Oxidative damage of several biomolecules is strongly involved in the pathogenesis of asthmatic inflammation. It is affecting airway functions causing an increase in the frequency of asthma attacks and deterioration. Aim: To determine Malondialdehyde level in both asthmatic children and the control group and to correlate its level to the degree of asthma severity.Subjects and Methods: Malondialdehyde (MDA) was measured in a group of Egyptian asthmatic children (55) and their matching controls (55) with an age range from 5 to 15 years who were attending the outpatient clinic in Suez Canal university hospital. Results: MDA level mean was higher in the studied asthmatic children than the control group being 3.32 ± 2.09 nmol/ml and 1.27 ± 0.20 nmol/ml respectively with a statistically significant difference. MDA level mean was found to correlate significantly and proportionally to the degree of asthma severity being 2.05 ±1.21 nmol/ml in intermittent asthma, 2.75 ± 1.75 nmol/ml in mild persistent, and 4.66 ± 2.12 nmol/ml in moderate persistent (p value<0.001). Conclusion:The findings of our study further strengthen the evidence that the altered oxidant-antioxidant balance is associated with airway obstruction.
 

DOI

10.21608/scumj.2023.299510

Keywords

Asthma, Oxidative Stress, antioxidant status, Free radicals, ROS

Authors

First Name

Marwa

Last Name

Mohamed

MiddleName

A.

Affiliation

Pediatric Department, Faculty of Medicine, Suez Canal University, Egypt

Email

marwaorabi@ymail.com

City

-

Orcid

-

First Name

Alaa El-Din

Last Name

Zeitoun

MiddleName

A.

Affiliation

Pediatric Department, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Fadia

Last Name

Attia

MiddleName

M.

Affiliation

Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Egypt

Email

fadiamostafa@gmail.com

City

-

Orcid

-

First Name

Nouran

Last Name

AbdAllah

MiddleName

B.

Affiliation

Pediatric Department, Faculty of Medicine, Suez Canal University, Egypt

Email

nouranb.abdallah@gmail.com

City

-

Orcid

0000-0002-8839-2680

Volume

26

Article Issue

2

Related Issue

41115

Issue Date

2023-02-01

Receive Date

2023-05-18

Publish Date

2023-02-01

Page Start

17

Page End

24

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 26_Issue 2_Pages 17-24.pdf

PDF . 351.0kB

Link

https://scumj.journals.ekb.eg/article_299510.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=299510

Order

3

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Correlation between Degree of Asthma Severity and Malondialdehyde in Asthmatic Children in Ismailia

Details

Type

Article

Created At

24 Dec 2024