ManageChatDiscover
297575

Serum Level of Survivin in Patients with Alopecia Areata and its Association with Disease Severity and Progression

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical Research (Medical)

Abstract

Background: Alopecia areata (AA) is an acquired cytotoxic T-cell immune-mediated hair loss disorder. The autoimmune attack triggers apoptosis with rapid progression of hair follicles (HFs) from the anagen to catagen and telogen phases of the hair cycle. Survivin is an inhibitor of apoptosis protein responsible for cell cycle regulation and apoptosis inhibition. Its expression has been determined in proliferating anagen HF cells, whereas its expression prominently decreases during the catagen phase. Aim: This study aimed to evaluate serum survivin level in AA patients and its relationship with AA severity and progression. Subjects and Methods: The study included 38 AA patients and 38 healthy controls. Alopecia areata severity was assessed by the severity of the Alopecia Tool score. Serum survivin level was measured by enzyme-linked immune-sorbent assay. Results: Serum Survivin level was significantly lower in AA patients than in controls (p < /em>= 0.009). Moreover, the level was significantly lower in patients with progressive disease than in those with stable disease (p < /em><0.001). A significant negative correlation was found between survivin serum level and AA severity (p < /em> < 0.001) and duration (p=0.003). Conclusion: Survivin serum level was decreased in AA patients. Thus, survivin could have a potential role in AA immune pathogenesis and its serum level might be a predictor for AA severity and progression.
 

DOI

10.21608/scumj.2023.297575

Keywords

hair follicles, Alopecia Areata, survivin, Autoimmunity

Authors

First Name

Hesham

Last Name

Nada

MiddleName

A.

Affiliation

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

profheshamnada@gmail.com

City

Ismailia

Orcid

0000 0001 7094 5462

First Name

Samah

Last Name

Gad EL- Hak

MiddleName

G.

Affiliation

Department of Dermatology and Venereology, Ministry of Health and Population, El-Tour General Hospital, South Saini, Egypt.

Email

dr.samah.gadelhak@gmail.com

City

-

Orcid

-

First Name

Nashwa

Last Name

Hassan

MiddleName

R.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Radwa

Last Name

Marie

MiddleName

E.

Affiliation

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

rivercruise84@gmail.com

City

-

Orcid

-

Volume

26

Article Issue

2

Related Issue

41115

Issue Date

2023-02-01

Receive Date

2023-05-03

Publish Date

2023-02-01

Page Start

1

Page End

9

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 26_Issue 2_Pages 1-9.pdf

PDF . 424.2kB

Link

https://scumj.journals.ekb.eg/article_297575.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=297575

Order

1

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Serum Level of Survivin in Patients with Alopecia Areata and its Association with Disease Severity and Progression

Details

Type

Article

Created At

24 Dec 2024