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292664

Assessment of Chemokine Motif Ligand 4 Gene Polymorphism in Rheumatoid Arthritis Patients and its Correlation with Disease Activity

Article

Last updated: 24 Dec 2024

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Tags

Clinical Research (Medical)

Abstract

Background The recent development of biological-based antirheumatic therapies that target inflammatory pathways in RA has enabled increasing numbers of patients to achieve very low levels of disease activity, yet a substantial proportion of RA patients remain treatment-refractory. CCL4 SNP is suspected to be one of these aberrations as it has been related to other diseases yet its role in RA is not well studied. Aim of work: this study aimed to assess the association between the chemokine motif ligand 4 (CCL4) Gene Polymorphism and susceptibility to RA disease and its correlation to the activity of the disease. Subjects and Methods this is a case-control study where CCL4 polymorphisms (SNPs1719153) genotyping and its relation to RA activity were assessed by a real-time PCR in 50 RA patients in comparison with age and sex-matched healthy control. Results: The results of the present study showed a non-statistically significant difference between the patients and controls in the distribution of the genotypes (AA/AT) and alleles (A/T) frequency. And no significant differences between these genotypes in terms of medication use, clinical status, or disease activity. Conclusion: CCL4 gene SNP rs1719153 genotypes (AA and AT) as well as CCL4 SNP rs1719153 alleles (A and T) did not significantly differ between RA patients and normal controls and had no relation to disease activity. To the best of our knowledge, this study is one of few studies to identify the distribution of rs1719153 SNPs in RA in the Egyptian population.

DOI

10.21608/scumj.2023.292664

Keywords

Rheumatoid Arthritis, CCl4, Polymorphism, SNPs

Authors

First Name

Fatma

Last Name

Elshamy

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

fatma.elshamy@live.com

City

-

Orcid

-

First Name

Hanan

Last Name

Omar

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

hananhassan1978@gmail.com

City

-

Orcid

-

First Name

Mohsen

Last Name

El-Shahaly

MiddleName

-

Affiliation

Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Amal

Last Name

Fathy

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

26

Article Issue

1

Related Issue

39420

Issue Date

2023-01-01

Receive Date

2023-03-29

Publish Date

2023-01-01

Page Start

92

Page End

99

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 26_Issue 1_Pages 92-99.pdf

PDF . 286.3kB

Link

https://scumj.journals.ekb.eg/article_292664.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=292664

Order

11

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Assessment of Chemokine Motif Ligand 4 Gene Polymorphism in Rheumatoid Arthritis Patients and its Correlation with Disease Activity

Details

Type

Article

Created At

24 Dec 2024